3,3-Difluorooxetane-A Versatile Functional Group for Bioisosteric Replacements in Drug Discovery.

Functional group (FG) is one of the cornerstone concepts in organic chemistry and related areas. The wide spread of bioisosterism ideas in medicinal chemistry and beyond caused a striking rise in demand for novel FGs with a defined impact on the developed compound properties. In this work, the evaluation of the 3,3-difluorooxetane unit (3,3-diFox) as a functional group for bioisosteric replacements is disclosed.

2-Azahetaryl-2-(oxoindolin-2-ylidene)acetonitriles as Colorimetric Probes for Zn: Synthesis and Optical Properties.

A new one-pot approach for the synthesis of the Zn-sensitive probes 2-azahetaryl-2-(oxoindolin-2-ylidene)acetonitriles and is described. The method includes the formation of imidoylchloride and its further condensation with azahetarylacetonitrile . The structure of the obtained compounds is studied using H nuclear magnetic resonance (NMR), C NMR, infrared (IR), high-resolution mass spectrometry (HRMS), and UV-Vis spectroscopy techniques.