Cellobiose-coated poly(lactide-co-glycolide) particles loaded with diphtheria toxoid for per os immunization.

Aim: To evaluate the dose-dependent immunogenic properties of poly(lactide-co-glycolide) (PLGA) particles coated with cellobiose as antigen carriers for oral immunization.

Methods: Two types of PLGA-cellobiose particles (PLGA-cellobiose-1, ~ 0.8 μm and PLGA-cellobiose-2, ~ 1.