Genotoxic and mutational potential of monocyclic terpenoids (carvacrol, carvone and thymol) in .

Genotoxicity and mutagenicity of monoterpene carvone along with the related monoterpene alcohols - carvacrol and thymol have been studied using as model system. The viability, pre-imaginal stage duration, level of dominant lethal mutations, unequal crossover in the mutant of and the influence of monocyclic terpenoids on the multiplication of the nuclear genome in salivary gland cells were investigated. The compounds tested after oral administration (0.

Toxic effect and genotoxicity of carvacrol ethers in Drosophila melanogaster.

The present study investigated the effect of four carvacrol ethers (propyl-, butyl, octyl- and benzyl) on the viability, level of dominant lethal mutations of Drosophila melanogaster and their influence on the multiplication of the nuclear genome in salivary gland cells. The fertility and viability of fruit flies were assessed after oral administration (0.05 % to culture medium) and inhalation exposure (5 mg per 1 cm of polyvinyl alcohol film) of compounds 1‒4 and initial carvacrol.