Publications by authors named "Tessa Van Buren"
Article Synopsis
- Loss-of-function mutations in the CLPB gene result in congenital neutropenia, impairing the differentiation of neutrophil precursor cells, though the underlying mechanism is unclear.
- In experiments using IL-3-dependent mouse myeloblastic 32Dcl3 cells, researchers found that CLPB knockout led to decreased mitochondrial membrane potential and increased HAX1 aggregates, but did not affect cell proliferation under IL-3.
- The increased apoptosis of CLPB-deficient cells after IL-3 withdrawal was linked to reactive oxygen species (ROS), with citrate supplementation showing potential to protect these cells by enhancing ROS detoxification through ATP-citrate lyase (ACLY) activity.
