Publications by authors named "Tess Orvis"
The NF-E2-related factor 2 (referred to as NRF2) transcription factor binds antioxidant responsive elements within the promoters of cytoprotective genes to induce their expression. Next-generation sequencing studies in lung cancer have shown a significant number of activating mutations within the NRF2 signaling pathway. Mutations in components of the SWI/SNF chromatin-remodeling complex, a general regulator of transcription using either BRG1 or BRM as the catalytic subunit, also frequently occur in lung cancers.
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- SWI/SNF complexes help control important cell processes like growth and how cells die, and their problems can lead to different types of cancer, including lung cancer.
- About 10% of lung cancers have an issue with a part called BRG1, which is important for these complexes.
- When BRG1 is not working right in lung cancer cells, it changes the shape of the cells and makes them more likely to become tumors while also affecting how certain cancer-related genes are expressed.
Eukaryotic organisms package DNA into chromatin for compact storage in the cell nucleus. However, this process promotes transcriptional repression of genes. To overcome the transcriptional repression, chromatin remodeling complexes have evolved that alter the configuration of chromatin packaging of DNA into nucleosomes by histones.
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