A case of ovarian endodermal sinus tumor associated with pregnancy.

A case of a 25-year-old 2 gravida, 1 para pregnant woman in the 7th week of gestation who was concurrented with endodermal sinus tumor (EST) is presented. Simple hysterectomy with left salpingo-oophorectomy, wedge resection of the right ovary and omentectomy were done following D & C. Histological features were identical to those described for EST by Teilum.

Bindings of cobra venom phospholipases A2 to micelles of n-hexadecylphosphorylcholine.

Bindings of cobra venom phospholipases A2 to micelles of n-hexadecylphosphorylcholine were studied by the tryptophyl fluorescence method at 25 degrees C and ionic strength 0.1. The data were analyzed by assuming that the micellar surface has multiple binding sites for the enzyme and these sites are identical and mutually independent.

[Fundamental and clinical studies of T-1982 (cefbuperazone) in the field of obstetrics and gynecology].

Tissue concentrations of T-1982 (cefbuperazone) at 100-220 minutes after the completion of 1 g/60 minutes dripping infusion were 8.9-10.6 micrograms/g in the uterus, ovary and oviduct.

Studies on the histogenesis of cervical adenocarcinoma.

The uterine cervices of 58 patients with cervical adenocarcinoma (seven in situ, 16 microinvasive, and 35 frank invasive) were studied along with 210 cervices that did not show any disease. Squamous metaplasia was confirmed in surface and cleft epithelium, but not in the deepest area of the gland-bearing portion of the cervix. Ectopic endometrial glands were observed in two of the 210 cases.

Participation of an ionizable group with pK 8.55 in the reaction of p-bromophenacyl bromide with His 48 of cobra venom phospholipases A2.

The chemical reaction of p-bromophenacyl bromide (BPB) with His 48 of cobra venom phospholipases A2 (N. naja siamensis, N. naja kaouthia, and N.

Progression of malignancy of severe dysplasia of the uterine cervix.

In the follow-up studies of dysplasia of the uterine cervix, the rates at which 691 cases of mild and 654 cases of severe dysplasia progressed to malignant lesions were, respectively, 0.3% (2 cases) and 17% (111 cases). A classification of the cases of severe dysplasia was made according to the degree of maturation of the lesion into immature, premature and mature dysplasia.

[Comparative nephrotoxicity of latamoxef and other cephalosporins in rabbits. Combined administration with furosemide or tobramycin. (author's transl)].

I. The nephrotoxic potential of latamoxef (LMOX, 6059-S) was evaluated in male rabbits after combined administration of 500 or 2,000 mg/kg of the compound (ear vein) with subcutaneous injection of furosemide (FUR) at 50 mg/kg. Histological examination of kidney tissues of all animals were performed after 72 hours.

Binding of substrate analogs to hen lysozyme in which Trp 62 is modified to kynurenine.

The interactions of beta-methyl-GlcNAc, (GlcNAc)2, and (GlcNAc)3 with hen egg-white lysozyme [EC 3.2.1.

Regulatory functions of hapten-reactive helper and suppressor T lymphocytes. III. Amplification of a generation of tumor-specific killer T-lymphocyte activities by suppressor T-cell-depleted hapten-reactive T lymphocytes.

2,4.6-trinitrophenyl (TNP)-reactive T-cell activities were raised in mice by immunization with TNP-isologous mouse gamma globulin. After establishing that TNP-reactive T lymphocytes can serve as amplifier cells for induction of killer T lymphocytes in allogeneic system, we explored the possibility of this hapten-reactive T-cell system to amplify tumor-specific killer T-lymphocyte activity in the syngeneic system.

Cytologic changes of cervical cancer according to the degree of invasion.

Cellular samples (cervical scrapings) obtained with wooden spatulas from patients with carcinoma in situ, early invasive cancer, and advanced cancer of the uterine cervix were examined. The number of malignant cells in the preparation increased with extent of the lesion. The granular chromatin structures of the nuclei of abnormal cells were observed in almost all cases, and the occurrence of irregularly distributed coarsely granular chromatin increased gradually with the extent of the cancer.

Preferential generation of killer or helper T-lymphocyte activity directed to the tumour-associated transplantation antigens.

Induction of killer and helper T-cell activities towards transplantation antigens of two tumour cell lines was analysed in the allogeneic and syngeneic host combinations. The lymphoid cells from C57BL/6 mice immunized with allogeneic viable or mitomycin C-treated X-5563 plasmacytoma cells derived from C3H/He mice revealed both killer and helper T-cell activities against alloantigens, whereas cells from mice immunized with tumour cells killed by a freezing and thawing procedure revealed predominantly helper T-cell activity. On the other hand, when C3H/He mice were immunized with viable syngeneic X-5563 plasmacytoma or MM102 mammary tumour cells, the former generated preferentially killer T-cell activity, whereas the latter induced predominantly helper T-cell activity against tumour-associated transplantation antigens.

Histopathologic criterion of dysplasia of the uterine cervix and its biological nature.

A histopathologic diagnostic standard for abnormal epithelium of the uterine cervix, based on its biological behavior, has been proposed, and dysplasia and carcinoma in situ have been classified according to this standard. Benign dysplasia by this classification may be considered as a benign lesion, and only the lesion which satisfies the standard for atypical dysplasia should be considered as dysplasia, having a significance as a precursor to cervical cancer. This would be clinically convenient.