Publications by authors named "Tesfaye Wolde"
Article Synopsis
- The study focuses on the role of Trefoil factor 3 (TFF3) in shaping the immunosuppressive tumor microenvironment (TME), which contributes to cancer progression and relapse.
- It found a strong association between TFF3 and PVRL2, indicating that they work together in various cancers to create an environment that supports tumor growth.
- The research also suggests that targeting both TFF3 and PVRL2 could lead to new therapeutic strategies, with potential drugs identified for inhibiting PVRL2.
A hyperactive tumour microenvironment (TME) drives unrestricted cancer cell survival, drug resistance, and metastasis in ovarian carcinoma (OC). However, therapeutic targets within the TME for OC remain elusive, and efficient methods to quantify TME activity are still limited. Herein, we employed an integrated bioinformatics approach to determine which immune-related genes (IRGs) modulate the TME and further assess their potential theragnostic (therapeutic + diagnostic) significance in OC progression.
View Article and Find Full Text PDFKitchen sponges are among the possible sources of contaminants in food establishments. The main purpose of the current study was, therefore, to assess the microbiological safety of sponges as it has been used in selected food establishments of Jimma town. Accordingly, the microbiological safety of a total of 201 kitchen sponges randomly collected from food establishments was evaluated against the total counts of aerobic mesophilic bacteria (AMB), Enterobacteriaceae, coliforms, and yeast and molds.
View Article and Find Full Text PDFBackground: Transfusion-transmissible infectious agents such as human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV), and Syphilis are among the greatest threats to blood safety for recipients. They are also the leading causes of death and chronic and life-threatening abnormalities.
Methods: A retrospective analysis of consecutive blood donors' records covering the period between January 2010 and December 2014 was conducted to analyze for seroprevalence of HIV, HBV, HCV and syphilis among blood donors aged 17-65 years.