Integrating Genomic, Transcriptomic, and Phenotypic information to Explore Drug Resistance in Mycobacterium tuberculosis sub-lineage 4.2.2.2.

Aims: Mycobacterium tuberculosis (Mtb) remains a major global health challenge, particularly due to increasing drug resistance. Beyond the well-characterized mutations, the mechanisms involved in driving resistance appear to be more complex. This study investigated the differential gene expression of Ethiopian drug-resistant Mtb sub-lineage 4.

Comparative growth kinetics and drug susceptibility of lineages prevalent in Ethiopia: implications for tuberculosis treatment and management.

Tuberculosis (TB) remains a global health challenge, with treatment outcomes influenced by the genetic diversity of () strains. This study examines the growth kinetics and drug susceptibility of strains from different lineages in Ethiopia to understand their impact on disease management. strains, including sub-lineages 4.