Tracking activities and adaptations in a multi-site stepped wedge pragmatic trial of a cancer symptom management intervention.

Background: Pragmatic trials may need to adapt interventions to enhance local fit, and adaptation tracking is critical to evaluation. This study describes the tracking approach for a multisite, stepped-wedge hybrid pragmatic trial testing implementation and effectiveness of a cancer symptom management intervention.

Methods: Study activities were documented in a spreadsheet by date and category.

The Longitudinal Implementation Strategy Tracking System (LISTS): feasibility, usability, and pilot testing of a novel method.

Background: Systematic approaches are needed to accurately characterize the dynamic use of implementation strategies and how they change over time. We describe the development and preliminary evaluation of the Longitudinal Implementation Strategy Tracking System (LISTS), a novel methodology to document and characterize implementation strategies use over time.

Methods: The development and initial evaluation of the LISTS method was conducted within the Improving the Management of SymPtoms during And following Cancer Treatment (IMPACT) Research Consortium (supported by funding provided through the NCI Cancer Moonshot).

Implementing cancer symptom management interventions utilizing patient-reported outcomes: a pre-implementation evaluation of barriers and facilitators.

Purpose: Symptoms can negatively impact quality of life for patients with a history of cancer. Digital, electronic health record (EHR)-integrated approaches to routine symptom monitoring accompanied by evidence-based interventions for symptom management have been explored as a scalable way to improve symptom management, particularly between clinic visits. However, little research has evaluated barriers and facilitators to implementing these approaches in real-world settings, particularly during the pre-implementation phase.

Neutral sphingomyelinase mediates the co-morbidity trias of alcohol abuse, major depression and bone defects.

Mental disorders are highly comorbid and occur together with physical diseases, which are often considered to arise from separate pathogenic pathways. We observed in alcohol-dependent patients increased serum activity of neutral sphingomyelinase. A genetic association analysis in 456,693 volunteers found associations of haplotypes of SMPD3 coding for NSM-2 (NSM) with alcohol consumption, but also with affective state, and bone mineralisation.

Rural Health Networks and Care Coordination: Health Care Innovation in Frontier Communities to Improve Patient Outcomes and Reduce Health Care Costs.

Rural residents' health is challenged by high health care costs, chronic diseases, and policy decisions affecting rural health care. This single-case, embedded design study, guided by community-based participatory research principles and using mixed methods, describes outcomes of implementation of a community care team (CCT) and care coordination to improve outcomes of patients living in a frontier community. Seventeen organizations and 165 adults identified as potential care coordination candidates constituted the target populations.

Performance test of different 3.5 mm drill bits and consequences for orthopaedic surgery.

Introduction: Drilling of bones in orthopaedic and trauma surgery is a common procedure. There are yet no recommendations about which drill bits/coating should be preferred and when to change a used drill bit.

Materials And Methods: In preliminary studies typical "drilling patterns" of surgeons concerning used spindle speed and feeding force were recorded.

Clamshell thoracotomy and open heart massage--A potential life-saving procedure can be taught to emergency physicians: An educational cadaveric pilot study.

Aims: Selected patients in traumatic cardiac arrest may benefit from pre-hospital thoracotomy. Pre-hospital care physicians rarely have surgical training and the procedure is rarely performed in most European systems. Limited data exists to inform teaching and training for this procedure.

Do the presence of pathologic changes and the level of operator experience alter the rate of intra-articular injection of the first metatarsophalangeal joint? A cadaver study.

Background: Injections, punctures, and aspirations of the first metatarsophalangeal joint are common interventions. Accurate intra-articular placement of the needle is a prerequisite for the achievement of desirable results and the avoidance of complications. We evaluated the rate of successful intra-articular injections and the influence of the degree of operator experience in achieving this success.

The risk of injury to the anterior tibial artery in the posterolateral approach to the tibia plateau: a cadaver study.

Background: Posterolateral tibial plateau shear fractures often require buttress plating, which can be performed through a posterolateral approach. The purpose of this study was to provide accurate data about the inferior limit of dissection.

Methods: Forty unpaired cadaver adult lower limbs were used.

Is sparing the pronator quadratus muscle possible in volar plating of the distal radius?

We measured the length of the distal radius that can be exposed by mobilizing the distal edge of pronator quadratus (PQ) without detaching its radial attachment. Measurements were made in 20 cadaveric upper limbs from the distal margin of the radius in line with the scaphoid and lunate fossae to the distal margin of the PQ, before and after mobilization of the muscle from its distal attachment. The mean distance from the distal edge of the PQ to the scaphoid fossa was 13.

Chemical composition and antibacterial activity of the essential oil of Lantana camara var. moritziana.

The essential oil obtained from the leaves of Lantana camara var. moritziana (Otto & Dietr.) López-Palacios collected at Rubio, Táchira State, Venezuela, was obtained by hydrodistillation in a Clevenger trap (0.

Anatomical structures at risk with the proud retrograde femoral nail.

Background: Post-operative knee pain is common following retrograde nailing, with its etiology often multifactorial although a well-established cause is nail protrusion from the intercondylar notch. The aim of this study was to assess the structures at risk if the nail is left proud of the femoral articular surface.

Methods: A retrograde femoral nail (Synthes Distal Femoral Nail) was inserted into the distal femur of 15 cadaveric lower limbs using the standard technique.

The risk of nerve injury with minimally invasive plate osteosynthesis of distal fibula fractures: an anatomic study.

Aim: The aim of our study was to identify the structures which may be at risk of injury when using a minimally invasive technique for the osteosynthesis of the lateral malleolus and the influence of the size of the implant on the frequency of injury to these structures.

Method: Forty plates were percutaneously inserted in 20 cadaveric legs. The region around the plate was then dissected to examine the relation of nerves and soft tissues to the plate.

Morphology of the tibialis anterior muscle and its implications in minimally invasive plate osteosynthesis of tibial fractures.

We examined the variation in the origin of the tibialis anterior muscle from the lateral aspect of the tibial shaft and interosseous membrane as well as the variation in the morphology of its musculotendinous junction. Forty cadaveric lower leg specimens (20 right and 20 left) were dissected to reveal the anterior compartment. The origin of the tibialis anterior muscle and its relation to the lateral tibial shaft and interosseous membrane were determined.

Intra-articular injection of the acromioclavicular joint.

Intra-articular punctures and injections are performed routinely on patients with injuries to and chronic diseases of joints, to release an effusion or haemarthrosis, or to inject drugs. The purpose of this study was to investigate the accuracy of placement of the needle during this procedure. A total of 76 cadaver acromioclavicular joints were injected with a solution containing methyl blue and subsequently dissected to distinguish intra- from peri-articular injection.

Anatomical basis of the risk of radial nerve injury related to the technique of external fixation applied to the distal humerus.

Purpose: Stabilization of humeral shaft and elbow fractures can be achieved with an external-fixator. Reports about nerve injuries associated with this procedure are rare in literature. Purpose of this anatomical study was to examine the relation of the radial nerve to distal humeral half pins.

[The dorsal approach to the radiocarpal joint: an anatomic variant and its clinical implications].

The extensor carpi radialis longus tendon and the extensor carpi radialis brevis tendon are important landmarks for the dorsoradial approach to the wrist. This case report presents an anatomic variant: both tendons are divided into two different reins. Knowledge about this anatomic variant is of importance in order to avoid misinterpretations.

The percutaneous antegrade scaphoid fracture fixation--a safe method?

Introduction: The object of this study was to assess the risk of injury to tendons, nerves and vessels in percutaneous antegrade scaphoid fracture fixation.

Methods: Forty cadaveric forearms were used in this study. A guide wire for cannulated headless compression screws was inserted percutaneously in each scaphoid according to established surgical technique.

Perforation of the third extensor compartment by the drill bit during palmar plating of the distal radius.

The frequency of penetration into the third extensor compartment when drilling the distal screw holes was assessed for four different palmar distal radius plates in 160 cadaver forearms. Penetration into this compartment occurred in 43%. Different plates had different penetration rates: 3.

The risk of iatrogenic injury to the deep peroneal nerve in minimally invasive osteosynthesis of the tibia with the less invasive stabilisation system: a cadaver study.

Percutaneous stabilisation of tibial fractures by locking plates has become an accepted form of osteosynthesis. A potential disadvantage of this technique is the risk of damage to the neurovascular bundles in the anterior and peroneal compartments. Our aim in this anatomical study was to examine the relationship of the deep peroneal nerve to a percutaneously-inserted Less Invasive Stabilisation System tibial plate in the lower limbs of 18 cadavers.

Various circular arc radii of the distal volar radius and the implications on volar plate osteosynthesis.

The purpose of this anatomical study was to explore the different circular arc radii of the distal volar radius and provide more detailed anatomic information that will further the understanding of volar plate osteosynthesis. The profiles of the volar distal radii of 100 cadaver specimens were measured with a common profile gauge. Profiles were copied onto paper and then matched to a best-fit circular arc template to determine the radius of curvature on the radial and ulnar sides of the distal volar radius.

Morphometric analysis of lister's tubercle and its consequences on volar plate fixation of distal radius fractures.

Purpose: The objective of this study was to measure the size and shape of Lister's tubercle and the depth of the extensor pollicis longus (EPL) groove to assess the risk of injury to the EPL tendon when performing volar plating of distal radius fractures.

Methods: The length and height of Lister's tubercle and the depth of the EPL groove were measured in 100 cadavers.

Results: The size of Lister's tubercle varied from 2 to 6 mm (average, 3.

Differences in length and cross-section of semitendinosus and gracilis tendons and their effect on anterior cruciate ligament reconstruction: a cadaver study.

The purpose of this anatomical study was to explore the morphological variations of the semitendinosus and gracilis tendons in length and cross-section and the statistical relationship between length, cross-section, and body height. We studied the legs of 93 humans in 136 cadavers. In 43 specimens (46.