Rare STAT3 haplotypes cause a predisposition to developing congenital anomalies of the kidney and urinary tract disorder.

Background/aim: Congenital anomalies of the kidney and urinary tract (CAKUT) are characterized by renal developmental disorders in the embryonic period. STAT3 is a member of the STAT protein family. The members of this protein family play roles in various cellular mechanisms, such as the early stages of embryonic development, kidney development, and renal diseases.

Determination of the Frequency of BCL-2 Polymorphisms (c.-717C>A and c.*2364G>A) and LIF Polymorphism (c.*1414T>G) in Patients with Congenital Anomalies of the Kidney and Urinary Tract.

Introduction: Congenital anomalies of the kidney and urinary tract (CAKUT) are characterized by several malformations. Its prevalence is 0.3-0.

Comparative analysis of protein profiles in skin secretions of some Rana species: Preliminary insights into antimicrobial activity.

Protein profiles of skin secretions of Rana dalmatina (Agile Frog), Rana macrocnemis (Uludağ Frog), Rana tavasensis (Tavas Frog) and Rana holtzi (Taurus Frog) frog species belonging to the Rana genus distributed in the Anatolian region of Türkiye were determined for the first time using the Tricine-SDS-PAGE Electrophoresis method and Coomassie Brilliant Blue (CBB) staining. By the results, some peptides with mass ≤5 kDa were detected. Just one peptide with mass ≤5 kDa was found in the secretion of each R.

Microplastic ingestion by invasive Prussian carp (Carassius gibelio) used in fishmeal production in Türkiye.

MP contamination in the gastrointestinal tract (GIT) of Prussian carp (Carassius gibelio) used in fishmeal production was examined. The samples were collected from Balık Lake, Karaboğaz Lake, and Liman Lake located in Kızılırmak Delta, Türkiye. The overall average abundance was 3.

Erratum: Clinical and Demographic Characteristics and Two-Year Efficacy and Safety Data of 508 Multiple Sclerosis Patients with Fingolimod Treatment.

[This corrects the article on p. 23 in vol. 60, PMID: 36911568.

The impact of developmental genes in non-syndromic cleft lip and/or palate.

Non-syndromic cleft lip and/or palate (NSCL/P) is a congenital malformation with a prevalence of 1:700 births. It has a multifactorial etiology. Human craniofacial development takes place during the first 10 weeks of pregnancy.

Clinical and Demographic Characteristics and Two-Year Efficacy and Safety Data of 508 Multiple Sclerosis Patients with Fingolimod Treatment.

Introduction: Fingolimod is the first oral immunomodulatory treatment used as secondary care therapy in the treatment of multiple sclerosis for the last 10 years. The objective of our study is to reveal the experiences of the first generic fingolimod active ingredient treatment in different centers across Turkey.

Method: The first generic fingolimod efficacy and safety data of patients followed-up in 29 different clinical multiple sclerosis units in Turkey were analyzed retrospectively.

From source to sink: A comparative study of streamside and beach litter in the Black Sea.

The increasing amount of marine litter pollution and its impact on the marine environment raises global concern. This study aims to reveal the effect of streams on marine litter density and composition. A total of ten stations on the southeastern Black Sea and six stations on the Manahoz stream were seasonally surveyed.

Potential application of cryogenic freezer on turbot sperm cryopreservation.

Background: Cryopreservation is a common practice to preserve fish sperm for prolonged periods.

Objective: To examine the effect of different freezing protocols on sperm characteristics, fertilization, and hatching rate of turbot.

Materials And Methods: Milt was obtained from ten 8-year-old turbot (54.

Spatial distribution and ecological risk evaluation of toxic metals in the southern Black Sea coastal sediments.

Spatial distribution and ecological risk levels of toxic metals (Cu, Pb, Zn, Ni, Co, As, Sr, V, and La) in sediments from the southern Black Sea coastal (Türkiye) were evaluated. The sediment samples were taken in April and May 2019 from thirty-one stations, from depths ranged between 16 and 65 m. The average metal concentrations (in dry weight) varied from 59.

Evaluation of toxic metals in different grain size fractions of sediments of the southeastern Black Sea.

Surficial marine sediment samples were collected along the southeastern Black Sea (Trabzon) coast. The sampling was conducted in June 2019 from eleven stations, with the depths varying between 8 and 30 m. Metal concentrations (Cu, Pb, Zn, Ni, As, and Cr) were evaluated in four different sediment size fractions; 0.

Associations between IL-1α, IL-1β, TNFα, and IL-6 variations, and susceptibility to transposition of the great arteries.

Background: To evaluate the relationship between IL-1α -889C/T (rs1800587), IL-1β -511C > T (rs16944), TNFα -308G > A (rs1800629), TNFα -238G > A (rs361525), IL-6 -174G > C (rs1800795), and IL-6 -572G > C (rs1800796) polymorphisms and the susceptibility to transposition of the great arteries (TGA).

Methods: A prospective analysis was performed on mothers whose newborns were diagnosed as having TGA. For each case of TGA, a mother who gave birth to a healthy neonate in the same period was randomly selected for the control group.

Solid waste composition and COVID-19-induced changes in an inland water ecosystem in Turkey.

The composition and abundance of solid waste and the effect of COVID-19 measures were studied in an inland water ecosystem in Turkey. Solid waste items were collected annually for 5 years from 2017 to 2021 from seven stations located in Borçka Dam Lake (B1-B4) and Murgul Stream (M1-M3) in the Artvin Province. The highest densities by number and weight were recorded at M3 in 2020 (5.

Clinical and molecular evaluation of MEFV gene variants in the Turkish population: a study by the National Genetics Consortium.

Familial Mediterranean fever (FMF) is a monogenic autoinflammatory disorder with recurrent fever, abdominal pain, serositis, articular manifestations, erysipelas-like erythema, and renal complications as its main features. Caused by the mutations in the MEditerranean FeVer (MEFV) gene, it mainly affects people of Mediterranean descent with a higher incidence in the Turkish, Jewish, Arabic, and Armenian populations. As our understanding of FMF improves, it becomes clearer that we are facing with a more complex picture of FMF with respect to its pathogenesis, penetrance, variant type (gain-of-function vs.

Spatial pattern and characteristics of the benthic marine litter in the southern Black Sea shelf.

The abundance and characteristics of benthic marine litter in the southern Black Sea shelf were demonstrated. During the surveys, 671 litter items weighing 83.93 kg were collected from the stations.

Microplastic contamination and characteristics spatially vary in the southern Black Sea beach sediment and sea surface water.

In this study, the abundance, and characteristics of the microplastics on the southern coast of the Black Sea were assessed. More than 70% of the detected microplastics were smaller than 2.5 mm and mostly consisted of fibers and fragments.

Isolation and molecular identification of industrially important enzyme producer yeasts from tree barks and fruits.

This study aimed to identify the yeast strains associated with the tree bark samples collected from the Aegean and Marmara regions and from rotten fruit samples. Fifty-one yeast strains were successfully isolated and screened for their abilities to produce industrially important extracellular enzymes. Thirty isolates demonstrated ability to produce at least two different enzymes and were selected for subsequent molecular identification using sequence analysis of ITS region and D1/D2 domain of the 26S rDNA.

Impact of Matrix Metalloproteinases 2 and 9 and Tissue Inhibitor of Metalloproteinase 2 Gene Polymorphisms on Allograft Rejection in Pediatric Renal Transplant Recipients.

Objectives: Acute and chronic allograft rejection have been continuously an important obstacle in the follow-up of renal transplant recipients. During clinical management, several factors acting simultaneously result in acute rejection and chronic allograft nephropathy. Matrix metalloproteinases and tissue inhibitors of metalloproteinases are responsible for the organization of the extracellular matrix and play roles in cell proliferation and cellular invasion.

Persistent Hyperinsulinemic Hypoglycemia with Pancreatic Teratoma in Infancy: A Case Report.

BACKGROUND Pediatric intraabdominal pancreatic teratomas have been rarely reported. This is the first case of severe hyperinsulinemic hypoglycemia in a 6-month-old infant secondary to an intraabdominal teratoma. The hypoglycemia resolved after surgical removal.

Population genetic structure of turbot (Scophthalmus maximus L., 1758) in the Black Sea.

Turbot, Scophthalmus maximus, is a commercially important demersal flatfish species distributed throughout the Black Sea. Several studies performed locally with a limited number of specimens using both mitochondrial DNA (mtDNA) and microsatellite markers evidenced notable genetic variation among populations. However, comprehensive population genetic studies are required to help management of the species in the Black Sea.

The Role of Heredity and the Prevalence of Strabismus in Families with Accommodative, Partial Accommodative, and Infantile Esotropia.

Objectives: To investigate the prevalence of strabismus in families of a proband with accommodative, partial accommodative, or infantile esotropia, and to evaluate the mode of inheritance and the role of consanguineous marriages in this prevalence.

Materials And Methods: Families of probands with comitant strabismus were invited to participate in the study. The family members of 139 subjects with accommodative, 55 with partial accommodative, and 21 with infantile esotropia agreed to participate.

Marine litter composition and sources on coasts of south-eastern Black Sea: A long-term case study.

Long-term monitoring of marine litter composition and density has been conducted between 2009 and 2018 on eleven beaches of Trabzon city located on the south-eastern Black Sea coast in Turkey. All unnatural litter items were collected from randomly selected transects on the beaches. A total of litter items 4138 in number and 108.