Publications by authors named "Teruyuki Hachiman"

Background: Cellulitis is a common disease in the elderly, and detecting etiologic organisms with blood cultures is difficult because of the low positive rate and occasional skin contamination. Therefore, routine blood cultures are not recommended for uncomplicated cellulitis. However, it is unclear whether blood culture collection for the diagnosis of cellulitis in elderly patients is useful.

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Enterobacteriaceae producing extended spectrum β-lactamase (ESBL) are distributed worldwide. In this study, 114 ESBL-producing Enterobacteriaceae were isolated by analyzing 1672 clinical isolates of Enterobacteriaceae collected from an Okinawa prefectural hospital in Japan between June 2013 and July 2014. The overall prevalence of ESBL-producing Enterobacteriaceae was 6.

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Despite a number of studies on the efficacies of antiseptics for the prevention of blood culture contamination, it still remains unclear which antiseptic should be used. Although the combination of povidone-iodine and isopropyl alcohol has been traditionally used in many institutions, the application of povidone-iodine needs extra time, and there is little evidence that this combination could have an additive effect in reducing contamination rates. To elucidate the additive efficacy of povidone-iodine, we compared two antiseptics, 70% isopropyl alcohol only and 70% isopropyl alcohol plus povidone-iodine, in a prospective, nonrandomized, and partially blinded study in a community hospital in Japan between 1 October 2007 and 21 March 2008.

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Article Synopsis
  • The study focuses on the activation of rat liver microsomal glutathione S-transferase (MGST1) by a specific protease found in the liver, which was identified as hepsin.
  • Hepsin is characterized as a type II transmembrane serine protease, and when incubated with MGST1, it significantly boosts MGST1 activity by 3-4.5 times over several days.
  • Analysis reveals that this incubation leads to the formation of MGST1 dimers and degradation fragments, indicating that hepsin acts both to activate and degrade MGST1 in liver microsomes.
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