Publications by authors named "Terumi Kawasaki"
Programs allowing access to investigational drugs and off-label drug use for serious diseases have often been applied to pediatric cancers. A clinical study conducted under the Japanese "Patient-Proposed Healthcare Services" evaluated the efficacy and safety of dabrafenib plus trametinib in children with BRAF V600 mutant glioma (jRCTs071210071). This study successfully provided unapproved and off-label medications to four enrolled patients, two with low-grade glioma and two with high-grade glioma (median age: 10.
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- The study examines how the social environment affects frailty in older adults with diabetes, with a focus on differences between urban and rural living conditions.
- Researchers analyzed data from 417 participants, finding that frailty was notably higher among those in rural areas (29.7% robust) compared to urban areas (43.9% robust), along with other negative health indicators.
- The findings suggest that older adults in rural areas face increased frailty risks due to lower performance in instrumental and social daily activities, highlighting the need for targeted intervention programs to improve social connections and care access.
Article Synopsis
- The study focused on the impact of diabetes medications on older adults (ages 60-80) with type 2 diabetes, particularly looking at their frailty and complications related to diabetes.
- A total of 417 participants were assessed using various health metrics and tests, revealing that many were either frail or pre-frail, with specific drug types linked to different health outcomes.
- Results showed that certain medications correlated with lower or higher risks of complications and frailty, emphasizing the need for tailored treatment in older diabetic patients.