Assessment of chromosome 19 for genetic association in severe chronic periodontitis.

Background: A genome-association study is a powerful tool for analyzing small gene effects in complex diseases such as chronic periodontitis (CP), although the cost of analysis is prohibitive. We designed a study using the DNA pooling method, which could be a breakthrough in lowering such costs. This study was conducted to assess the genetic association in severe CP in a Japanese population.

Genome-wide association analysis with selective genotyping identifies candidate loci for adult height at 8q21.13 and 15q22.33-q23 in Mongolians.

We performed a genome-wide association study with 23,465 microsatellite markers to identify genes related to adult height. Selective genotyping was applied to extremely tall and extremely short individuals from the Khalkh-Mongolian population. Two loci, 8q21.

[The effects of intrathecally administered neostigmine on somato-sympathetic reflex potentials].

Background: Antinociceptive effect of intrathecal neostigmine has been investigated using withdrawal responses in laboratory experiments. However, neostigmine administered in this route can induce muscle weakness or sedation. As a result, these effect can modify withdrawal responses.

[The effects of intrathecally administered baclofen on somato-sympathetic reflex potentials].

We investigated the antinociceptive effect of intrathecally administered S(-)-baclofen and R (+)-baclofen in cats using somato-sympathetic reflex potentials derived from lumbar sympathetic ganglion by stimulation of the femoral nerve. S(-)-baclofen 10 mg maximally reduced both A reflex potential and C reflex potential to 65.3% and 83.