Publications by authors named "Teruaki Yamaguchi"
Article Synopsis
- The KEAP1-NRF2 system is crucial for managing oxidative stress and inflammation, where NRF2 is activated when its inhibitor KEAP1 is downregulated.
- Bromovalerylurea (BU), previously known for its sedative properties, demonstrates anti-inflammatory effects, though its exact mechanism was unknown.
- Recent findings show that BU enhances NRF2 activity in liver and brain cells, promoting protective gene transcription and reducing inflammation, indicating its potential as a novel therapeutic agent for controlling oxidative stress and inflammation.
Cerebral ischemia/reperfusion injury activates microglia, resident immune cells in the brain, and allows the infiltration of circulating immune cells into the ischemic lesions. Microglia play both exacerbating and protective roles in pathological processes and are thus often referred to as "double-edged swords." In ischemic brains, blood-borne macrophages play a role that is distinct from that of resident activated microglia.
View Article and Find Full Text PDF