The relationship between WAIS PA and MMPI SI is mediated by MMPI PD.

Investigated the effects of MMPI PD on the relationship between WAIS PA and MMPI SI. WAIS PA performance and MMPI SI have been reported to be related negatively in university undergraduates (Schill, 1966) and related positively in psychiatric patients (Johnson, 1969). This study was derived from the assumption that Schill's undergraduates had higher MMPI PD than Johnson's patients.

Polytetrafluoroethylene reconstruction of the inferior vena cava.

Three successful cases of reconstruction of the inferior vena cava (one of the bifurcation) by polytetrafluoroethylene grafts suggest further trial of this solution for a difficult and hitherto unsolved problem.

Interferon-induced growth modulation: low dose maintenance of the antiproliferative response.

Treatment of the Burkitt's lymphoma-derived Daudi cell line with human beta interferon (HuIFN-beta) results in a dose-dependent antiproliferative response. We have defined three phases including: (1) initiation, (2) maintenance, and (3) termination of the antiproliferative state. Each phase is characterized by specific growth modulatory properties.

Sex-related differences in pineal gland N-acetyltransferase induction by d-amphetamine.

The activity of the rat pineal gland enzyme, N-acetyltransferase (NAT), was measured to determine if amphetamine stimulation of norepinephrine release from sympathetic fibers innervating the gland varies according to sex-dependent mechanisms. Pineal gland NAT activity was increased following amphetamine treatment to a greater extent and for a longer duration in adult female rats compared to male animals. The greater in vivo stimulation of adult female pineal gland NAT activity by the drug developed after puberty, depended upon intact gonads, and apparently was not due to sex differences in the amount of norepinephrine released by the drug from sympathetic nerves when tested under in vitro conditions.

Immunohistochemical localization of carcinoembryonic antigen (CEA), CEA-S, and nonspecific cross-reacting antigen (NCA) in carcinomas of lung.

Antisera to carcinoembryonic antigen (CEA), to a physicochemical subset of CEA, namely CEA-S, and to nonspecific cross-reacting antigen (NCA) were used for the immunohistochemical localization of these antigens in human bronchogenic carcinomas using a triple layer immunoperoxidase technique. The study is based on an analysis of tumors from 130 patients. CEA, CEA-S, and NCA were all identified in the membrane and/or cytoplasm of neoplastic cells, and a good correlation between the antigens was observed in a majority of tumors.

Senile dementia of the Alzheimer type.

The prevalence of severe dementia in the United States is about 1.3 million cases, of which at least 50 to 60% are of the Alzheimer type. Severe dementia of the Alzheimer type is found rarely in a clearly dominant pattern, although often one or more relatives are affected.

The effect of eyeglasses on self-esteem.

Self-esteem of optometric patients was shown to be affected by when eyeglasses were first prescribed but not by the length of time they had been worn. Glasses have more negative effects on self-esteem when first prescribed during childhood or adulthood than during adolescence. Children may be more likely than adolescents to internalize negative social reactions evoked by glasses, whereas adults who obtain glasses may be reacting negatively to evidence of aging and physical decline.

Does weight loss cause the exercise-induced increase in plasma high density lipoproteins?

Studies showing an increase in plasma concentration of high density lipoprotein cholesterol (HDL-C) with moderate exercise have usually rejected the role of body weight change in the HDL-C raising process, ostensibly because the amount of weight lost has been negligible. To investigate HDL-C changes more thoroughly, we followed initially sedentary middle-aged men randomly assigned to either a moderate running (n = 36) or a sedentary control (n = 28) group for one year. Among runners, one-year changes in plasma HDL-C concentrations correlated strongly with their body weight changes (r = - 0.

Quantitative assessment of dietary adherence in patients with insulin-dependent diabetes mellitus.

Research on the education of diabetic patients in diet management suffers from lack of an adequate method for describing patients' dietary behavior. In this report, a method is proposed for the quantitative assessment of dietary adherence in patients with IDDM. The method relies on comparisons between individualized diet plans and actual consumption as reflected by 24-h diet recalls.

Distribution of cholinergic neurons in rat brain: demonstrated by the immunocytochemical localization of choline acetyltransferase.

The neuroanatomical location and cytological features of cholinergic neurons in the rat brain were determined by the immunocytochemical localization of the biosynthetic enzyme, choline acetyltransferase (ChAT). Perikarya labeled with ChAT were detected in four major cell groups: (1) the striatum, (2) the magnocellular basal nucleus, (3) the pontine tegmentum, and (4) the cranial nerve motor nuclei. Labeled neurons in the striatum were observed scattered throughout the neostriatum (caudate, putamen) and associated areas (nucleus accumbens, olfactory tubercle).

Surgical treatment of carcinoma of the breast. I. Pathological finding and pattern of relapse.

This is a retrospective review of 476 patients who had mastectomy for carcinoma of the breast during 1971-1980. There is a positive correlation of size of the primary tumor and the incidence of axillary nodal metastasis. Infiltrating ductal and lobular carcinoma had a significantly higher incidence of nodal metastasis (and greater change of having four or more positive nodes) than that of medullary and colloid carcinomas.

Immunocytochemical comparison of neurofibrillary tangles in senile dementia of Alzheimer type, progressive supranuclear palsy, and postencephalitic parkinsonism.

Antiserum raised against a two-cycle-purified human brain microtubule fraction that binds specifically to tangles of senile dementia of the Alzheimer type was tested on the subthalamus, basis pontis, and midbrain sections of two patients with progressive supranuclear palsy. Tangles composed of 15 nm straight fibers in these areas showed positive immunolabeling with the antiserum. The labeling tangles appeared as a fibrous meshwork in neuronal cell bodies and occasionally in short segments of axons.

Monoclonal antibodies to choline acetyltransferase: production, specificity, and immunohistochemistry.

Immunohistochemical localization of choline acetyltransferase (ChAT) in cholinergic neurons has been difficult to achieve because of problems encountered in producing specific antisera. Here we describe the production and characterization of several distinct monoclonal antibodies to ChAT. Each of the monoclonal antibodies exhibits one of three general patterns of cross-species reactions; one pattern shows reactivity limited mainly to bovine ChAT, a second pattern shows reactivity only to ChAT from higher mammals including humans, and the third pattern shows reactivity to ChAT from all mammals tested.

Determination of niacin metabolites 1-methyl-5-carboxylamide-2-pyridone and N-1-methylnicotinamide in urine by high-performance liquid chromatography.

A test suitable for detecting latent niacin deficiency was developed. It measures the 24-h urinary output of the two major metabolites of niacin, 1-methyl-5-carboxylamide-2-pyridone and N-1-methylnicotinamide. The two metabolites were isolated from urine using separate ion-exchange extractions.

Biopsy of peripheral lymph nodes.

This retrospective study reviews 653 patients who had peripheral lymph node biopsies for purposes of diagnosis from 1973 to 1977. Overall, 56 per cent of the nodes had benign lesions, 29 per cent had carcinoma, and 15 per cent had lymphoma. Supraclavicular nodes had the highest incidence of metastatic carcinoma (54%), and inguinal nodes had the highest incidence of reactive hyperplasia or lymphadenitis (71%).