Synthesis and Bioactivity of a Cyclopolypeptide from Caribbean Marine Sponge.

Synthesis of a natural proline-rich cyclopolypeptide - rolloamide A was carried out by coupling of tri- and tetrapeptide units Boc-Phe-Pro-Val-OMe and Boc-Pro-Leu-Pro-Ile-OMe after proper deprotection at carboxyl and amino terminals using carbodiimide chemistry in alkaline environment followed by cyclization of linear heptapeptide segment in the presence of base. The structure of synthesized peptide was confirmed by spectral techniques including FTIR, H NMR, C NMR, MS analyses. Newly synthesized peptide was subjected to biological screening against pathogenic microbes and earthworms.

Identification of calcium, sodium, magnesium and chloride ion levels in hypertensive and non-hypertensive trinidadians.

Hypertension is a progressive cardiovascular disease with association to risk factors. These risk factors in conjunction with essential elements has become identifiable with the development of the progressive disease. The key purpose of this investigation was to identify the levels of the essential elements, Sodium (Na), Magnesium (Mg), Chloride (Cl) and Calcium (Ca) in both hypertensive and non-hypertensive patients in a Trinidadian population.

Application of a novel sex independent anthropometric index, termed angle index, in relation to type 2 diabetes: a Trinidadian case-control study.

Objective: To develop a novel sex independent anthropometric index, termed as angle index, related to type 2 diabetes.

Design: Case-control.

Participants: The study comprised 121 participants and were divided into two groups.

Evaluation of vitamin D relationship with type 2 diabetes and systolic blood pressure.

Objective: To investigate whether relationships exist among vitamin D, type 2 diabetes mellitus (T2DM), and blood pressure in Trinidadian subjects with T2DM.

Research Design And Methods: This was a case-controlled study to determine if vitamin D levels were lower in patients with T2DM. After data analysis, an exploratory hypothesis of vitamin D relationship to systolic blood pressure (SBP) was developed.