Effects of Obstructive Sleep Apnea and Obesity on Cardiac Remodeling: The Wisconsin Sleep Cohort Study.

Study Objectives: To characterize the prospective associations of obstructive sleep apnea (OSA) with future echocardiographic measures of adverse cardiac remodeling.

Methods: This was a prospective long-term observational study. Participants had overnight polysomnography followed by transthoracic echocardiography a mean (standard deviation) of 18.

Association between asthma and risk of developing obstructive sleep apnea.

Importance: Obstructive sleep apnea (OSA) is more common among patients with asthma; whether asthma is associated with the development of OSA is unknown.

Objective: To examine the prospective relationship of asthma with incident OSA.

Design, Setting, And Participants: Population-based prospective epidemiologic study (the Wisconsin Sleep Cohort Study) beginning in 1988.

Combined effects of sleep disordered breathing and metabolic syndrome on endothelial function: the Wisconsin Sleep Cohort study.

Study Objectives: To examine the combined impact of sleep disordered breathing (SDB) and metabolic syndrome (MetS) in endothelial dysfunction.

Design: Cross-sectional assessment of endothelial function, MetS and SDB status in a population-based sample.

Setting: Community-based cohort.

The effects of sleep-disordered breathing on arterial stiffness are modulated by age.

Study Objectives: To identify associations between sleep-disordered breathing (SDB) and arterial stiffness.

Setting: Nested cross-sectional study.

Participants: One hundred fifty-three participants (ages 45-77 years, 43% women) in the population-based Wisconsin Sleep Cohort.

Sleep disordered breathing and metabolic syndrome.

Background: Sleep disordered breathing (SDB) has been associated with cardiovascular disease, hypertension, and insulin resistance. This article examines the association between SDB and the prevalence of metabolic syndrome (MS) in a community-based sample.

Methods: A subset of participants in the Wisconsin Sleep Cohort Study (N=546) participated in an ancillary study to measure vascular and metabolic function.

Sleep-disordered breathing and cardiovascular disease: an outcome-based definition of hypopneas.

Rationale: Epidemiologic studies on the consequences of sleep-disordered breathing invariably use the apnea-hypopnea index as the primary measure of disease severity. Although hypopneas constitute a majority of disordered breathing events, significant controversy remains about the best criteria used to define these events.

Objectives: The current investigation sought to assess the most appropriate definition for hypopneas that would be best correlated with cardiovascular disease.

The parable of parabola: what the U-shaped curve can and cannot tell us about sleep.

The Finnish Twin Cohort and in Great Britain, The Whitehall II Cohort--both endowed with rich covariate data. Associations between short and long sleep durations and mortality were first noted by Hammond in 1964 in the American Cancer Society I study, and they later achieved notoriety when presented by Kripke et al in 1979 (see reference 5 for a review of studies with similar findings.) Although the number and specificity of publications to further explore these controversial findings rapidly increased, most studies relied on the association of sleep duration measured at a single time point with followed-up mortality.

Epidemiology of daytime sleepiness: definitions, symptomatology, and prevalence.

Daytime sleepiness, or difficulty in maintaining a desired level of wakefulness, is frequently viewed by the general population as a common experience and predictable consequence of insufficient sleep. However, daytime sleepiness can have a serious impact on an individual's health, safety, and quality of life. Despite the fact that population-based studies have found that 1 in 5 adults suffers from daytime sleepiness, there is a lack of consistency in how daytime sleepiness is defined, measured, and interpreted, which may affect the medical management of the disorder.

The relationship between chronically disrupted sleep and healthcare use.

Study Objectives: To determine whether chronic sleep deprivation, sleep disruption, sleepiness, insomnia, and OSA are associated with increased healthcare use in a community-based population.

Design: Cross-sectional study.

Setting/participants: 6440 Sleep Heart Health Study (SHHS) participants recruited from ongoing cohort studies.

Evidence for recent increases in obesity and non-insulin-dependent diabetes mellitus in a Navajo community.

Historic and current biomedical data were used to quantify changes in obesity and non-insulin-dependent diabetes mellitus (NIDDM) over a 30 year period in a Navajo community. Medical charts from an earlier study (1955-1961) provided data on 827 adults. Field-based methods yielded data from 231 adults during a health survey in 1988.

The relationship of body fat distribution to non-insulin-dependent diabetes mellitus in a Navajo community.

The relationship between non-insulin-dependent diabetes mellitus (NIDDM) and body fat distribution (BFD) as measured by waist/hip circumference (WHR) was investigated in a Navajo community. A sample of 136 females and 89 males, 20 years and older, was recruited using a cluster-sampling design. Fifty percent of the females and 30.