Comparison of Performance between the Elecsys 4 and 5 Generation STAT Cardiac Troponin T Immunoassays.

Objective: To evaluate the analytical and clinical performance of the 5 GEN cTnT assay by comparing it with the 4 GEN assay.

Methods: Imprecision, analytical measurement range (AMR), reference interval, and quantitative comparison were studied. Qualitative comparisons of the two assays for randomly selected patients with the cTnT test orders and patients with elevated N-terminal proB-type natriuretic peptide (NT-proBNP), decreased estimated glomerular filtration rate (eGFR), and increased procalcitonin were performed.

Analytical and Clinical Analysis of Two Automated Anti-SARS-CoV-2 Immunoassays in Pre-Pandemic and Pandemic Patient Populations.

Background: In the absence of a safe, effective vaccine, the worldwide spread of COVID-19 (SARS-CoV-2) infection will continue. Laboratory tests with ideal precision, sensitivity, and specificity should be used in public health and clinical settings to gauge the extent of virus exposure. Toward this end, we evaluated the analytical and clinical performance of the Abbott SARS-CoV-2 IgG and the Roche Anti-SARS-CoV-2 immunoassays.

Automated Measurement of Plasma Cell-Free Hemoglobin Using the Hemolysis Index Check Function.

Background: The Roche Cobas chemistry analyzer's hemolysis index (HI) check function can directly report hemoglobin (Hb) concentrations. We aimed to validate the HI check function for the measurement of plasma cell-free Hb.

Methods: Plasma samples (6 μl) were taken by the analyzer and diluted in normal saline to measure the absorbance for Hb at 570 and 600 nm.