Malignant phyllodes tumour of the breast with early recurrence in a young patient.

A young woman in her 20s was found to have a left breast malignant phyllodes tumour by ultrasound-guided core needle biopsy, after identifying a palpable lump. She then underwent lumpectomy excision with >1 cm gross margins; however, final pathology demonstrated <1 cm margins at the superior margin. She then underwent re-excision of superior and medial margins to ensure at least a 1 cm margin.

Characteristics of pathologic complete response for locally advanced rectal cancer.

Background: Neoadjuvant chemoradiation (NACRT) is the standard of care for locally advanced rectal cancers. The purpose of this study was to determine patient and tumor factors associated with a pathologic complete response (pCR).

Methods: The National Surgical Quality Improvement Program proctectomy-targeted database was utilized to identify all patients from 2016 to 2020 who underwent NACRT followed by proctectomy with curative intent for T3-4N0-2 rectal cancers.

Quantifying Human Monocyte Chemotaxis In Vitro and Murine Lymphocyte Trafficking In Vivo.

Chemotaxis is migration along a specific chemical gradient. Chemokines are chemotactic cytokines that promote cellular trafficking with anatomic and temporal specificity. Chemotaxis is a critical function of lymphocytes and other immune cells that can be quantitatively assessed in vitro.