Interhospital Transfer Delays Appropriate Treatment for Patients With Severe Sepsis and Septic Shock: A Retrospective Cohort Study.

Objective: To test the hypothesis that interhospital transfer causes significant delays in the administration of appropriate antibiotics and compliance with the completion of Surviving Sepsis Bundle elements.

Design: Single-center retrospective cohort study.

Setting: A comprehensive 60,000-visit emergency department at a 711-bed Midwestern academic medical center.

Kinetic and Mechanistic Aspects of Sulfur Recovery from Pd(2)I(2)(&mgr;-S)(&mgr;-dpm)(2) Using I(2) and Structures of Pd(II) Complexes with the Chelated Monosulfide of dpm.

The Pd(2)X(2)(&mgr;-S)(dpm)(2) complexes (2) (X = I, Br) react with halogens to yield PdX(2)(dpm) (3) and elemental sulfur. Kinetic and mechanistic studies on the X = I system in CHCl(3) reveal that the reaction proceeds via addition of I(2) to give Pd(2)I(4)(dpm)(2) (4c), which then undergoes unimolecular decomposition to generate PdI(2)(dpm) (3c); the liberated sulfur concatenates to form elemental S(8). The addition reaction is in the stopped-flow time regime and is first-order in both 2c and I(2), with DeltaH() = 32 +/- 1 kJ mol(-)(1) and DeltaS() = -91 +/- 3 J K(-)(1) mol(-)(1).