[Indexes of local cytokine status in individuals with intestine dysbacteriosis].

Aim: Determination of the content of various cytokines in coprofiltrates of individuals with bacteriologically confirmed intestine dysbacteriosis.

Materials And Methods: Qualitative and quantitative content of large intestine microbiocenosis was studied; IFNγ, pro-inflammatory (IL-2, IL-6, IL-8, IL-1β) and anti-inflammatory (IL-4, IL-10) content was determined using EIA in coprofiltrates of 139 individuals aged 18 - 60 years. All the indexes were juxtaposed with the cytokine index (CI): RESULTS.

[Indexes of immunity and local protection in humans with intestine dysbacteriosis].

Aim: Study indexes of immunity and local protection in humans with intestine dysbacteriosis.

Materials And Methods: Qualitative and quantitative intestine microbiocenosis, content of gamma-interferon (EIA method) in coprofiltrates in 204 individuals were studied, data from immunograms of 123 individuals with bacteriologically confirmed dysbacteriosis were analyzed.

Results: The presence of immune deficiency mainly by T-cell type was established in 92.

[Features of microbiocenosis composition of large intestine of humans with various degree of local metabolic disorders].

Aim: Detection of features of qualitative and quantitative composition of large intestine microbiocenosis of humans with various degree of local metabolic disorders during dysbacterioses due to various causes.

Materials And Methods: Microflora of large intestine and content of malonic dialdehyde (MDA) in coprofiltrates of 330 adult humans with large intestine dysbacterioses due to various causes were studied.

Results: It was established, that high MDA content in coprofiltrates matches higher quantities of opportunistic microorganisms and atypical escherichia in microflora composition of large intestine.

[Biochemical criteria for severity of colonic dysbacteriosis].

The purpose of the investigation was to estimate the content of malondialdehyde (MDA) in the coprofiltrates of human beings with bacteriologically verified colonic dysbacteriosis and to clarify a relationship of the amount of MDA in the coprofiltrates to the degree of the abnormal qualitative and quantitative composition of microbiocenosis. Specimens from 109 subjects aged 19 to 56 years were examined. The change in the level of MDA in the coprofiltrates was found to correspond to the impairment in the composition of microbiocenosis.

[Measures of local non-specific resistance during of colon dysbiosis].

Aim: To study several parameters of local non-specific resistance during development of experimental dysbiosis caused by administration of wide spectrum antibiotic.

Materials And Methods: Objects of the study were colonocytes and coprofiltrates from 120 outbred mice developing experimental dysbiosis, in which activity of antioxidant enzymes (superoxid dismutase [SOD] and catalase) and level of one of the final product of lipid peroxidation--malondialdehyde (MDA).

Results: Decrease of SOD and catalase activity and significant increase of MDA level during development of experimental dysbiosis were established, which were associated with decreased activity of oxygen-dependent bactericidal systems of colonocytes and changes in composition of colon microbiocenosis.

[Microbiocenosis of large intestine in persons with dysfunctional disorders of biliary tract].

Aim: To study prevalence of hemolytic Escherichia in microbiocenosis of large intestine in 501 adult persons from Rostov-on-Don city.

Materials And Methods: Comparison of qualitative and quantitative composition of large intestine microbiocenosis in 248 persons with ultrasound examination of functional state of biliary tract was performed.

Results: Statistically significant dependence of the rate of hemolytic Escherichia detection in microflora of large intestine from presence of dysfunctional disorders of biliary tract (biliary tract dysfunction) was revealed.

[Determination of the enterotoxigenicity of conditionally pathogenic microorganisms using the method of suppressing the dehydrogenase activity of the UV mutant Staphylococcus aureus 209 P].

The S. aureus 209P UF mutant dehydrogenase activity suppression method was used for detection of enterotoxin of Enterobacteriaceae opportunistic bacteria. Comparison of V.

[Neuraminidase activity of staphylococci].

141 S. aureus and S. epidermidis strains, isolated from the personnel of obstetric wards by taking smears from the anterior sections of the nose, have been tested for their capacity for neuraminidase production.

[Antibiotic sensitivity of Staph. aureus strains isolated from the upper respiratory tracts of healthy carriers].

Sensitivity of 1004 cultures of Staph. aureus isolated from the upper respiratory tracts of the staff of a maternity hospital was studied by the method of serial dilutions in agar with respect to 11 antibiotics. It was found that 61.

[Antagonistic interrelationships between the staphylococci and Sarcina isolated from the upper respiratory tracts of virtually healthy persons].

The antagonistic activity of staphylococci isolated from the mucosa of the anterior parts of the nose of practically healthy persons was studied with respect to 102 strains of Sarcinia. Staphylococcus aureus had the most pronounced inhibitory effect on Sarcinia. No difference in the antagonistic activity of the staphylococci isolated from the carriers of the permanent and transitory types was found.