ThF thin films for solid-state nuclear clocks.

After nearly 50 years of searching, the vacuum ultraviolet Th nuclear isomeric transition has recently been directly laser excited and measured with high spectroscopic precision. Nuclear clocks based on this transition are expected to be more robust than and may outperform current optical atomic clocks. These clocks also promise sensitive tests for new physics beyond the standard model.

Rethinking Shared Decision-Making: Delivery of Care Options in a Telehealth World.

Telehealth modalities have given patients options for delivery of care, and in some cases increased access to care. However, great effort needs to be made by providers and clinic staff to ensure patients are given choice in their delivery of care methods and technological support to work toward equity in care. We propose applying the BEACH model for shared decision-making to help providers support patients in choosing the best care delivery method, while also encouraging providers to seek further education on telehealth competencies.

Cost Effectiveness of Definitive Treatment Strategies for Autonomously Functioning Thyroid Nodules.

Objective: Autonomously functioning thyroid nodules (AFTN) can be treated with antithyroid drugs, radioactive iodine (RAI), thyroid lobectomy or radiofrequency ablation (RFA). Although surgery is most definitive, some patients require lifelong hormone supplementation. RFA avoids this sequela, but its efficacy depends on nodule size.

Laser Excitation of the ^{229}Th Nuclear Isomeric Transition in a Solid-State Host.

LiSrAlF_{6} crystals doped with ^{229}Th are used in a laser-based search for the nuclear isomeric transition. Two spectroscopic features near the nuclear transition energy are observed. The first is a broad excitation feature that produces redshifted fluorescence that decays with a timescale of a few seconds.

Laparoscopic surgery for adrenocortical carcinoma: Estimating the risk of margin-positive resection.

Background: Over recent years, there has been increasing adoption of minimally invasive surgery (MIS) in the treatment of adrenocortical carcinoma (ACC). However, MIS has been associated with noncurative resection and locoregional recurrence. We aimed to identify risk factors for margin-positivity among patients who undergo MIS resection for ACC.

Masking release at 4 and 32 kHz in harbor seals associated with sinusoidal amplitude-modulated masking noise.

Masking can reduce the efficiency of communication and prey and predator detection. Most underwater sounds fluctuate in amplitude, which may influence the amount of masking experienced by marine mammals. The hearing thresholds of two harbor seals for tonal sweeps (centered at 4 and 32 kHz) masked by sinusoidal amplitude modulated (SAM) Gaussian one-third octave noise bands centered around the narrow-band test sweep frequencies, were studied with a psychoacoustic technique.

Insurance Coverage of Prophylactic Mastectomies: A National Review of the United States.

Background: Breast cancer is associated with a multitude of risk factors, such as genetic predisposition and mutations, family history, personal medical history, or previous radiotherapy. A prophylactic mastectomy (PM) may be considered a suitable risk-reducing procedure in some cases. However, there are significant discrepancies between national society recommendations and insurance company requirements for PM.

Assessing potential perception of shipping noise by marine mammals in an arctic inlet.

Shipping is increasing in Arctic regions, exposing marine mammals to increased underwater noise. Noise analyses often use unweighted broadband sound pressure levels (SPL) to assess noise impacts, but this does not account for the animals' hearing abilities at different frequencies. In 2018 and 2019, noise levels were recorded at five and three sites, respectively, along a shipping route in an inlet of Northern Baffin Island, Canada.

Treat Now or Treat Later: Comparative Effectiveness of Adjuvant Therapy in Resected Stage IIIA Melanoma.

Background: Adjuvant therapy for most sentinel-node-positive (stage IIIA) melanoma may have limited clinical benefit for older patients given the competing risk of non-cancer death. The objective of this study is to model the clinical effect and cost of adjuvant therapy in stage IIIA melanoma across age groups.

Study Design: A Markov decision analysis model simulated the overall survival of patients with resected stage IIIA melanoma treated with adjuvant therapy vs observation.

Masking release at 4 kHz in harbor porpoises (Phocoena phocoena) associated with sinusoidal amplitude-modulated masking noise.

Acoustic masking reduces the efficiency of communication, prey detection, and predator avoidance in marine mammals. Most underwater sounds fluctuate in amplitude. The ability of harbor porpoises (Phocoena phocoena) to detect sounds in amplitude-varying masking noise was examined.

Contralateral prophylactic mastectomy in the setting of breast cancer diagnosis and their insurance coverage in the United States.

Background: Contralateral prophylactic mastectomy (CPM) is more common in the United States than the rest of the world. However, the benefit of this procedure is still under question in many breast cancer scenarios. CPM utilization in the United States is in part dependent on a patient's health insurance coverage of breast oncology surgery and any desired reconstruction.

Access to maternity and prenatal care services in rural Michigan.

Background: The United States physician shortages affect rural health care access, including maternity care. Project aims were to identify and characterize prenatal and delivery care in Michigan's rural counties and to explore access to trial of labor after cesarean (TOLAC) services for women in rural Michigan.

Methods: Descriptive, cross-sectional design used 2015 Medicaid claims data and public health plan information to identify maternity care services provided within Michigan's rural counties.

Effectiveness of Cathelicidin Antimicrobial Peptide against Ictalurid Catfish Bacterial Pathogens.

One of the major goals in aquaculture is to protect fish against infectious diseases as disease outbreaks could lead to economic losses if not controlled. Antimicrobial peptides (AMPs), a class of highly conserved peptides known to possess direct antimicrobial activities against invading pathogens, were evaluated for their ability to protect Channel Catfish Ictalurus punctatus and hybrid catfish (female Channel Catfish × male Blue Catfish I. furcatus) against infection caused by the fish pathogen Aeromonas hydrophila ML09-119.

Temporary hearing threshold shift in harbor seals (Phoca vitulina) due to one-sixth-octave noise bands centered at 0.5, 1, and 2 kHz.

This study concludes a larger project on the frequency-dependent susceptibility to noise-induced temporary hearing threshold shift (TTS) in harbor seals (Phoca vitulina). Here, two seals were exposed to one-sixth-octave noise bands (NBs) centered at 0.5, 1, and 2 kHz at several sound exposure levels (SELs, in dB re 1 μPas).

Weddell seals produce ultrasonic vocalizations.

Seals (phocids) are generally not thought to produce vocalizations having ultrasonic fundamental frequencies (≥20 kHz), although previous studies could have been biased by sampling limitations. This study characterizes common, yet, previously undescribed, ultrasonic Weddell seal (Leptonychotes weddellii) vocalizations. The vocalizations were identified in more than one year (2017-2018) of broadband acoustic data obtained by a continuously recording underwater observatory in McMurdo Sound, Antarctica.

CRISPR/Cas9-mediated knock-in of alligator cathelicidin gene in a non-coding region of channel catfish genome.

CRISPR/Cas9-based gene knockout in animal cells, particularly in teleosts, has proven to be very efficient with regards to mutation rates, but the precise insertion of exogenous DNA or gene knock-in via the homology-directed repair (HDR) pathway has seldom been achieved outside of the model organisms. Here, we succeeded in integrating with high efficiency an exogenous alligator cathelicidin gene into a targeted non-coding region of channel catfish (Ictalurus punctatus) chromosome 1 using two different donor templates (synthesized linear dsDNA and cloned plasmid DNA constructs). We also tested two different promoters for driving the gene, zebrafish ubiquitin promoter and common carp β-actin promoter, harboring a 250-bp homologous region flanking both sides of the genomic target locus.

Cathelicidins enhance protection of channel catfish, Ictalurus punctatus, and channel catfish ♀ × blue catfish, Ictalurus furcatus ♂ hybrid catfish against Edwarsiella ictaluri infection.

Cathelicidins are a class of antimicrobial peptides (AMPs) known to possess rapid and direct antimicrobial activities against a variety of microorganisms. Recently identified cathelicidins derived from alligator and sea snake were found to be more effective in inhibiting microbial growth than other AMPs previously characterized. The ability of these two cathelicidins along with the peptides, cecropin and pleurocidin, to protect channel catfish (Ictalurus punctatus, Rafinesque) and hybrid catfish (I.

Migrant status and risk of compulsory admission at first diagnosis of psychotic disorder: a population-based cohort study in Sweden.

Background: Minority ethnic and migrant groups face an elevated risk of compulsory admission for mental illness. There are overlapping cultural, socio-demographic, and structural explanations for this risk that require further investigation.

Methods: By linking Swedish national register data, we established a cohort of persons first diagnosed with a psychotic disorder between 2001 and 2016.

The Community Navigator Study: Results from a feasibility randomised controlled trial of a programme to reduce loneliness for people with complex anxiety or depression.

Background: Loneliness is common among people with mental health problems and predicts poorer recovery from depression and anxiety. Needs for support with loneliness and social relationships are often under-addressed in mental health services. The Community Navigator programme was designed to reduce loneliness for adults (aged 18 and above) with complex depression or anxiety who were using secondary mental health services.

Temporary hearing threshold shift in harbor seals (Phoca vitulina) due to a one-sixth-octave noise band centered at 32 kHz.

Two female harbor seals were exposed for 60 min to a continuous one-sixth-octave noise band centered at 32 kHz at sound pressure levels of 92 to 152 dB re 1 μPa, resulting in sound exposure levels (SELs) of 128 to 188 dB re 1 μPas. This was part of a larger project determining frequency-dependent susceptibility to temporary threshold shift (TTS) in harbor seals over their entire hearing range. After exposure, TTSs were quantified at 32, 45, and 63 kHz with a psychoacoustic technique.

Temporary hearing threshold shift in harbor seals (Phoca vitulina) due to a one-sixth-octave noise band centered at 40 kHz.

As part of a series of studies to determine frequency-dependent susceptibility to temporary hearing threshold shifts (TTS), two female harbor seals (F01 and F02) were exposed for 60 min to a one-sixth-octave noise band centered at 40 kHz at mean sound pressure levels ranging from 126 to 153 dB re 1 μPa [mean received sound exposure level (SEL) range: 162-189 dB re 1 μPas]. TTSs were quantified at 40, 50, and 63 kHz within 1-4 min of the exposure for F02 and within 12-16 min of the exposure for F01. In F02, significant TTS (1-4 min post exposure) occurred at 40 kHz with SELs of ≥183 dB re 1 μPas and at 50 kHz with SELs of ≥174 dB re 1 μPas.

Impacts of florfenicol on the microbiota landscape and resistome as revealed by metagenomic analysis.

Background: Drug-resistant fish pathogens can cause significant economic loss to fish farmers. Since 2012, florfenicol has become an approved drug for treating both septicemia and columnaris diseases in freshwater fish. Due to the limited drug options available for aquaculture, the impact of the therapeutical florfenicol treatment on the microbiota landscape as well as the resistome present in the aquaculture farm environment needs to be evaluated.