Publications by authors named "Terhi J Huuskonen"
Purpose: The purpose of our study was to examine the long-term outcomes of operated Chiari malformation type 1 (CM1) patients and evaluate whether different duraplasty techniques affected outcome after surgery in Kuopio University Hospital catchment area.
Methods: In this retrospective study, a total of 93 patients were diagnosed with CM1 and underwent posterior fossa decompression surgery with or without duraplasty between 2005 and 2020. All patients' medical records were examined for baseline characteristics, surgical details, and long-term follow-up data after operation.
Article Synopsis
- The study focused on aneurysmal intracerebral hemorrhage (aICH), highlighting the absence of personalized patient timelines and detailed brain imaging throughout treatment and recovery.
- Researchers analyzed 54 patients who underwent surgical clipping for a specific type of aneurysm, compiling data from emergency calls to clinical outcomes using timeline and imaging panels.
- Findings indicate that larger aICH volumes at the time of admission were linked to higher rates of rebleeds and mortality, emphasizing the need for timely intervention and enhanced imaging during surgery to monitor recovery.
Article Synopsis
- The study explores the relationship between pre-eclampsia and saccular intracranial aneurysms (sIAs), focusing on female patients, their relatives, and matched controls, to assess the prevalence of pre-eclampsia in these groups.
- It analyzed data from 265 female sIA patients, their female relatives, and a control group, revealing a higher prevalence of pre-eclampsia in sIA patients (11%) compared to matched controls (6%).
- The findings indicate that pre-eclampsia is more common among sIA patients, with familial occurrences observed in seven families, suggesting a need for further research into how pre-eclampsia may increase the risk of sIA rupture.
Purpose: Our review of acute brain insult articles indicated that the patients' individual (i) timeline panels with the defined time points since the emergency call and (ii) serial brain CT/MRI slice panels through the neurointensive care until death or final brain tissue outcome at 12 months or later are not presented.
Methods: We retrospectively constructed such panels for the 45 aneurysmal subarachnoid hemorrhage (aSAH) patients with a secondary decompressive craniectomy (DC) after the acute admission to neurointensive care at Kuopio University Hospital (KUH) from a defined population from 2005 to 2018. The patients were indicated by numbers (1.
Background And Purpose: Pathophysiological studies of saccular intracranial aneurysm (sIA) disease have shown that inflammation plays a crucial role in sIA development. Pharmaceutical inhibition of COX-2-PGE2-NF-κB signaling (COX-2, cyclooxygenase-2; PGE2, prostaglandin E2; NF-κB, nuclear factor κB) has been shown in animal models to inhibit sIA formation and progression suggesting that use of medication inhibiting COX-2 could reduce intracranial aneurysm formation also in patients.
Methods: The impact of COX-2 inhibition on de novo sIA formation was studied in two cohorts: in a previously described angiographically followed cohort of 1419 sIA patients and in a cohort of 117 sIA patients treated with stenting or stent-assisted embolization.
Background And Purpose: Hypertension is a risk factor for subarachnoid hemorrhage and is also considered a risk factor for saccular intracranial aneurysm (sIA) formation. However, there is little direct evidence that antihypertensive medication will reduce sIA formation.
Methods: The impact of antihypertensive medication on de novo sIA formation was studied in an angiographically followed cohort of 1419 patients.
Article Synopsis
- - The study aimed to investigate the occurrence of pre-eclampsia, gestational hypertension, chronic hypertension, and gestational diabetes in pregnant women with saccular intracranial aneurysms (sIAs).
- - Researchers analyzed medical records of 169 patients with sIA from 1990 to 2015, finding that 13% had pre-eclampsia and 19% experienced other hypertensive issues, compared to 5% and 10% in matched controls, respectively.
- - The findings suggest pre-eclampsia is more common in women with sIA, and those with pre-eclampsia tended to have irregularly shaped aneurysms, indicating a need for further research on
Background: Idiopathic intracranial hypertension (IIH) is a rare disease of unknown aetiology related possibly to disturbed cerebrospinal fluid (CSF) dynamics and characterised by elevated intracranial pressure (ICP) causing optic nerve atrophy if not timely treated. We studied CSF dynamics of the IIH patients based on the available literature and our well-defined cohort.
Method: A literature review was performed from PubMed between 1980 and 2020 in compliance with the PRISMA guideline.
Background: Shunt-dependent hydrocephalus after aneurysmal subarachnoid hemorrhage (aSAH) is a common sequelae leading to poorer neurological outcomes and predisposing to various complications.
Methods: A total of 2191 consecutive patients with aSAH were acutely admitted to the Neurointensive Care at the Kuopio University Hospital between 1990 and 2018 from a defined population. A total of 349 (16%) aSAH patients received a ventriculoperitoneal shunt, 101 with an adjustable valve (2012-2018), 232 with a fixed pressure valve (1990-2011), and 16 a valveless shunt (2010-2013).
Background: To study the clinical condition of poor-grade aneurysmal subarachnoid hemorrhage (aSAH) patients alive at 3 years after neurointensive care.
Methods: Of the 769 consecutive aSAH patients from a defined population (2005-2015), 269 (35%) were in poor condition on admission: 145 (54%) with H&H 4 and 124 (46%) with H&H 5. Their clinical lifelines were re-constructed from the Kuopio Intracranial Aneurysm Database and Finnish nationwide registries.