Publications by authors named "Terezia Hudakova"
DNA topoisomerases regulate conformational changes in DNA topology during normal cell growth, such as replication, transcription, recombination, and repair, and may be targeted for anticancer drugs. A DNA topology assay was used to investigate DNA-damaging/protective activities of extracts from Habanero Red (HR), Habanero Maya Red (HMR), Trinidad Moruga Scorpion (TMS), Jalapeno (J), Serrano pepper (SP), Habanero Red Savina (HRS), Bhut Jolokia (BJ), and Jamaica Rosso (JR) peppers, demonstrating their inhibitory effect on the relaxation of pBR by Topo I. DNA topoisomerase II (Topo II) is proven therapeutic target of anticancer drugs.
View Article and Find Full Text PDFPolymorphisms at 1q32, 8q24, and 17q22 loci are associated with nonsyndromic cleft lip with or without cleft palate risk in the Slovak population.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub
June 2017
Article Synopsis
- Nonsyndromic cleft lip with or without cleft palate (nsCL/P) is a common birth defect influenced by genetic and environmental factors, with several genetic variants linked to its risk.
- The study focused on four specific single nucleotide polymorphisms (SNPs) identified in previous research and analyzed their association with nsCL/P in a Slovak population.
- Significant differences were found in allele and genotype frequencies for three SNPs, suggesting they may increase the risk of nsCL/P, while one SNP displayed a trend toward association.
Background: We aimed to analyse quantitative effects of treatment with sulphonylurea in addition to metformin on parameters of glycemic control in relation to KCNQ1 genotypes, and to identify factors predictive for the response to sulphonylurea treatment.
Material/methods: Effect of 6-month sulphonylurea therapy in addition to metformin on glycemic control according to KCNQ1 genotypes was evaluated in 87 patients with type 2 diabetes who failed to achieve glycemic control on metformin monotherapy. KCNQ1 rs163184 (T>G) polymorphism was determined by real-time PCR with melting analysis of unlabeled probe.