Effects of two chronic stress models on ligature-induced periodontitis in Wistar rats.

Objectives: The present study aims at comparing the effects of physical and variable chronic stress on ligature-induced periodontitis in rats.

Design: Forty-eight adult Wistar rats were randomly assigned to four groups (n=12): physical stress, variable stress, positive control and negative control. The models of physical stress were immobilization and immobilization associated with exposure to cold.