Value of PET ECG gating in a cross-validation study of cardiac function assessment by PET/MR imaging.

Background: This work investigated the impact of different cardiac gating methods on the assessment of cardiac function by FDG-PET in a cross-validation PET/MR study.

Methods And Results: MR- and PET-based left ventricular end-diastolic, end-systolic volumes, and ejection fraction (EDV, ESV, and EF) were delineated in 30 patients with a PET/MR examination. Cardiac PET imaging was performed using three ECG gating methods: fixed number of gates per beat (STD), STD with a beat acceptance window (STD-BR), and fixed gate duration (FW).

MR-guided motion-corrected PET image reconstruction for cardiac PET-MR.

Simultaneous PET-MR imaging has shown potential for the comprehensive assessment of myocardial health from a single examination. Furthermore, MR-derived respiratory motion information has been shown to improve PET image quality by incorporating this information into the PET image reconstruction. Separately, MR-based anatomically guided PET image reconstruction has been shown to perform effective denoising, but this has been so far demonstrated mainly in brain imaging.

Hybrid PET/MR imaging for the prediction of left ventricular recovery after percutaneous revascularisation of coronary chronic total occlusions.

Purpose: To evaluate myocardial viability assessment with hybrid 2-deoxy-2-[F]fluoro-D-glucose positron emission tomography/magnetic resonance imaging ([F]FDG-PET/MR) in predicting left ventricular (LV) wall motion recovery after percutaneous revascularisation of coronary chronic total occlusion (CTO).

Methods And Results: Forty-nine patients with CTO and corresponding wall motion abnormality (WMA) underwent [F]FDG-PET/MR imaging for viability assessment prior to percutaneous revascularisation. After 3-6 months, 23 patients underwent follow-up MR to evaluate wall motion recovery.

Motion-corrected whole-heart PET-MR for the simultaneous visualisation of coronary artery integrity and myocardial viability: an initial clinical validation.

Purpose: Cardiac PET-MR has shown potential for the comprehensive assessment of coronary heart disease. However, image degradation due to physiological motion remains a challenge that could hinder the adoption of this technology in clinical practice. The purpose of this study was to validate a recently proposed respiratory motion-corrected PET-MR framework for the simultaneous visualisation of myocardial viability (F-FDG PET) and coronary artery anatomy (coronary MR angiography, CMRA) in patients with chronic total occlusion (CTO).