Publications by authors named "Teresa Toral"
Article Synopsis
- - The study explored the use of Direct Oral Drug Provocation Test (DODPT) to safely assess beta-lactam antibiotic (BLA) allergies in children, revealing that over 90% of suspected cases could be ruled out effectively.
- - It involved 2,133 young patients across 15 hospitals in Spain, noting that most had mild reactions; only a handful experienced severe reactions, such as anaphylaxis, which resolved quickly with treatment.
- - The results suggest that DODPT is a reliable method for confirming or denying BLA allergies, making it a practical option for doctors in pediatric care to help "delabel" unnecessary allergies.
Positive drug provocation with beta-lactam antibiotics in children: A single test may not be enough.
Allergol Immunopathol (Madr)
September 2022
Background: Drug provocation tests (DPTs) are considered the gold standard for diagnosing beta-lactam allergy. However, positive results tend to be mild and difficult to interpret. This study aimed to describe pediatric patients with a presumedly positive or inconclusive DPT, assess the decision to repeat the DPT, and describe its outcome.
View Article and Find Full Text PDFEpidemiology of pediatric parapneumonic pleural effusion during 13-valent pneumococcal conjugate vaccine implementation.
Enferm Infecc Microbiol Clin (Engl Ed)
August 2022
Introduction: The reported incidence of parapneumonic pleural effusion, including empyema, has shown fluctuations in the last decades. It has been related to the implementation of different types of conjugate pneumococcal vaccines.
Methods: We have retrospectively reviewed data from all 10 public hospitals in Alicante Province (Spain) covering a population of 279,000 children under 15 years of age, between 2010 and 2018.
Article Synopsis
- PM-allergoids are new vaccines designed to target dendritic cells and induce Treg cells, with this study focusing on their safety and optimal dosage for treating house dust mite allergies in humans.
- In a clinical trial with 196 participants, doses of PM-HDM were compared against placebos using various administration routes (subcutaneous and sublingual) over four months, measuring key outcomes like nasal provocation tests and symptom scores.
- Results showed that PM-HDM was safe, with significant improvements in allergy symptoms observed at higher doses, particularly at 3000 mTU for sublingual administration and 5000 mTU for subcutaneous administration.
Drug reexposure in children with severe mucocutaneous reactions.
Allergol Immunopathol (Madr)
March 2022
In pediatric patients, severe cutaneous adverse reactions (SCARs) frequently occur in the course of acute illnesses, mostly infections, which are usually treated with antibiotics or analgesics. The drug provocation test (DPT) is contraindicated in such situations, due to the risk of triggering a new severe reaction. As a consequence, lifelong avoidance is recommended.
View Article and Find Full Text PDFThe most appropriate treatment for parapneumonic effusion (PPE), including empyema, is controversial. We analyzed the experience of our center and the hospitals in its reference area after adopting a more conservative approach that reduced the use of chest tube pleural drainage (CTPD). Review of the clinical documentation of all PPE patients in nine hospitals from 2010 to 2018.
View Article and Find Full Text PDFBurden of severe 2009 pandemic influenza A (H1N1) infection in children in Southeast Spain.
Enferm Infecc Microbiol Clin
December 2011
Introduction: Most of the published studies on patients admitted with 2009 pandemic influenza are not population based. We have compiled the clinical information regarding all children admitted with 2009 pandemic influenza A (H1N1) infection during the season 2009-2010 in our defined population, in order to have an unbiased view of the most severe side of the clinical spectrum of the infection and to quantify its burden.
Methods: Children <15 years-old admitted to any of 3 hospitals in South-East Spain with 2009 pandemic influenza A (H1N1) detected by means of reverse transcriptase polymerase chain reaction.