Publications by authors named "Teresa Song"
Article Synopsis
- Botulinum type-A toxin is widely used for aesthetic and medical treatments, but type-B toxin is gaining interest for patients resistant to type-A.
- The study reviewed FDA-approved uses of rimabotulinumtoxinB and off-label indications, highlighting its varying effectiveness depending on the condition treated.
- Type B toxin is safe and effective for conditions like facial wrinkles, cervical dystonia, sialorrhea, and hyperhidrosis, although common side effects include dry mouth and dysphagia. It shows faster action and a dose-dependent effect profile.
Article Synopsis
- Topical ruxolitinib, a JAK inhibitor, is effective for inflammatory skin conditions like atopic dermatitis and vitiligo, with potential for other skin issues.* -
- A case series presented four patients with resistant dermatological conditions, including lichen sclerosus and morphea, who showed significant improvement using ruxolitinib cream.* -
- The findings support the use of ruxolitinib as a viable treatment option and suggest the need for further formal evaluations.*
Alopecia areata (AA) has been recently shown to also include T-helper cell type 2/IL-23 activation, in addition to T-helper cell type 1/IFN-skewing. The success of Jak inhibition together with IL-4Rα antagonism and limited response to IL-17A and PDE4 (protein) inhibition in AA are increasing our understanding of the complex immune interplay in AA. Trials testing targeted therapeutics are needed to further elucidate the pathogenic contribution of various cytokines.
View Article and Find Full Text PDFBackground: Moderate-to-severe atopic dermatitis (AD) has been associated with significant disease burden and systemic abnormalities and often requires systemic treatments. Currently, safe and effective oral systemic treatments for moderate-to-severe AD are not yet available. ASN002 is an oral inhibitor of the Janus kinase/spleen tyrosine kinase signaling pathways, targeting several cytokine axes (T2/T22/T17/T1) and epidermal differentiation.
View Article and Find Full Text PDFThe ichthyoses are rare skin disorders with immune and barrier aberrations. Identifying blood phenotypes may advance targeted therapeutics. We aimed to compare frequencies of skin homing/cutaneous lymphocyte antigen (+) versus systemic/cutaneous lymphocyte antigen (-) "polar" CD4/CD8 and activated T-cell subsets in ichthyosis versus atopic dermatitis, psoriasis, and control blood, with appropriate clinical correlations.
View Article and Find Full Text PDFAn individual's behavior is generally based on genetic blueprint and previous experiences. A coping strategy, affected by personal interpretation of past events, can be determined by behavioral controllability of stress. In this study, we examined the relationship between the hippocampal mGluR5 expression and coping strategies to stress.
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