Publications by authors named "Teresa Piliant"
Genet Epigenet
October 2015
Article Synopsis
- The study examines how STAT5, a signaling protein, misbinds to genes involved in inflammation in monocytes from Type 1 diabetic humans.
- Researchers used genetically modified mice (B6.NOD C11bxC1tb) to model these changes, demonstrating that specific genetic regions combined with STAT5 binding lead to altered expression of inflammatory genes CSF2 and PTGS2.
- These modified mice showed symptoms of diabetes, such as high blood sugar and pancreatic damage, suggesting that the gene expression changes in immune cells may increase diabetes risk even in mice that are not typically prone to autoimmune diseases.
