Publications by authors named "Teresa Pecere"
Article Synopsis
- Aloe-emodin (AE) is an active compound found in various plants used in traditional medicine and has been identified as a new antitumor agent, particularly effective against neuroblastoma cells.
- The study reveals that AE enters tumor cells through two specific somatostatin receptors, SSTR2 and SSTR5, and these findings were supported by multiple experimental methods including gene silencing and imaging.
- SSTR2 was consistently found in all analyzed surgical neuroblastoma samples, suggesting significant potential for AE's clinical use as a targeted anticancer treatment.
Previously, we have identified aloe-emodin (AE) as a new type of anticancer agent, with activity that is based on apoptotic cell death promoted by a neuroectodermal tumor-specific drug uptake. We attempt to clarify the intracellular target of AE and the apoptosis-signaling pathway activated by AE in neuroblastoma cell lines. Two-photon excitation microscopy and spectroscopic titrations documented that AE is highly concentrated in susceptible cells and binds to DNA.
View Article and Find Full Text PDFNew anti-human immunodeficiency virus type 1 6-aminoquinolones: mechanism of action.
Antimicrob Agents Chemother
March 2003
A 6-aminoquinolone derivative, WM5, which bears a methyl substituent at the N-1 position and a 4-(2-pyridyl)-1-piperazine moiety at position 7 of the bicyclic quinolone ring system, was previously shown to exhibit potent activity against replication of human immunodeficiency virus type 1 (HIV-1) in de novo-infected human lymphoblastoid cells (V. Cecchetti et al., J.
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