Absence of blood donors' anti-SARS-CoV-2 antibodies in pre-storage leukoreduced red blood cell units indicates no role of passive immunity for blood recipients.

Transfer of vaccine antibodies (Ab) from donors to recipients after transfusion of packed red blood cells (RBC) is supposed, thus affecting the recipients' response to vaccinations. In this prospective study, SARS-CoV-2 IgG level in donors' serum and RBC supernatant samples was assessed. Among 346 subjects, 280 were referred for hyperimmune plasma donation and 30 for whole blood donations.

Natural history of malignant bone disease in gastric cancer: final results of a multicenter bone metastasis survey.

Background: Bone metastasis represents an increasing clinical problem in advanced gastric cancer (GC) as disease-related survival improves. In literature, few data on the natural history of bone disease in GC are available.

Patients And Methods: Data on clinicopathology, skeletal outcomes, skeletal-related events (SREs), and bone-directed therapies for 208 deceased GC patients with evidence of bone metastasis were statistically analyzed.

[Mesial-temporal lesions in patients with neurosyphilis].

Background And Purpose: Evaluate and describe clinical and imaging findings in two patients with mesial-temporal changes in a context of Neurosyphilis.

Methods: The clinical files of two patients with mesial-temporal lesions in the context of Neurosyphilis were reviewed, gathering information about sex, age, clinical presentation, laboratory and EEG changes, treatment and clinical outcome. An emphasis was placed in the initial and follow-up MR studies.

[The development of the cerebral venous system--from the embryo to the adult definitive structure].

Introduction: The human development consists of a continuous process where an uninterrupted pattern of extremely complex repetitive cycles of growth, modulation and modification take place. Despite this extreme complexity, the normal development is ordered by an impressive regularity, namely, in chronological, anatomical, topographic and physiological trends. In some organic systems, this development will not be totally ended by the time of birth.

[Anatomy and variants of the cerebral venous system--fact or defect?].

Unlabelled: The anatomy of the cerebral venous system (CVS) is based on a known variable three-dimensional structure. For a correct recognition and characterization of its elements, a detailed knowledge of its anatomy and potential variants is essential. However, this structural changes, commonly named as variants, may appear in asymptomatic situations as well as associated to certain pathological syndromes with diagnostic and therapeutic consequences.

[Pemetrexed monotherapy in previously treated patients with advanced non small cell lung cancer; differences by histology. Our experience].

Emerging data suggest pemetrexed is active in patients with adenocarcinoma of lung compared to those with squamous cell carcinoma. We retrospectively reviewed advanced non small cell lung cancer (NSCLC) patients previously treated, analysing efficacy on histologic characteristics. From January 2007 to December 2010, 25 patients with stage IIIB or IV NSCLC (17 with adenocarcinoma and 8 with squamous cell carcinoma), who had previously failed on platinum-based chemotherapy, received pemetrexed 500 mg/mq every 3 weeks until disease progression or unacceptable toxicities.

The outcome of elderly patients with cognitive complaints but normal neuropsychological tests.

Elderly patients may present with prominent cognitive complaints and have performances in neuropsychological tests within the normal range for the age and education, and thus do not fulfill the criteria for mild cognitive impairment (MCI). There is insufficient evidence to support the clinical decision in these cases ("pre-MCI"). Forty-three subjects, 11 controls, 15 "pre-MCI," and 17 MCI, were followed for about three and half years with neuropsychological testing and magnetic resonance imaging including volumetric measurements of the hippocampus and amygdala.

[Angio-CT in atheromatous carotid disease].

CT angiography is a diagnostic tool, which is rapidly becoming an important modality for non-invasive evaluation of the neurovasculature. The aim of this article is to review this method, including acquisition and image processing protocols and its application for the evaluation of atherosclerotic stenosis of the carotid artery. Illustrative cases are shown and a revision of the literature is also made.

[Evaluation of cerebral glioma with advanced magnetic resonance techniques].

Magnetic Resonance Imaging (MRI) is the technique of choice for the radiological evaluation of cerebral gliomas. Determination of its malignant grade is important for therapeutic approach and prognosis. The authors focus on the utility of MRI advanced techniques, namely proton magnetic resonance spectroscopy, perfusion and diffusion.

Weekly low-dose docetaxel in advanced hormone-resistant prostate cancer patients previously exposed to chemotherapy.

Objective: The aim of this study was to evaluate the activity and tolerability of docetaxel in patients with hormone-resistant prostate cancer previously exposed to chemotherapy.

Methods: We enrolled 27 patients with hormone-resistant prostatic cancer that had progressed during first-line chemotherapy. The primary end-point was palliative response defined as a 2-point reduction in the 6-point present pain intensity scale, and an improvement in Karnofsky performance status of one 10-point category.