Anti-inflammatory and anti-oxidative effects of herbal preparation EM 1201 in adjuvant arthritic rats.

Background And Objective: The purpose of the present study was to examine the anti-arthritic and antioxidant effects of herbal and active organic ingredient complex (EM 1201) in rats with experimental adjuvant arthritis (AA).

Materials And Methods: AA was induced in 30 male Wistar rats by intradermal injection of complete Freund's adjuvant into the left hind paw. The course of disease in 30 rats in response to the treatment with EM 1201 and diclofenac, the parameters including body weight, joint swelling, blood indices pro-/antioxidant status of blood serum, and histology of joints and the liver, were investigated.

Non-specific immunity-enhancing effects of tryptic casein hydrolysate versus Fermosorb for treatment/prophylaxis of newborn calf colibacillosis.

The effects of treatment/prophylaxis of newborn calf colibacillosis with tryptic casein hydrolysate (TCH), recently shown to be a novel type of antimicrobial acting through stimulation of the microbial autolytic system, versus an authorized veterinary drug, Fermosorb, were evaluated. Both products showed similar high therapeutic and prophylactic efficacies, but hematological indices and daily weight gain of cured/protected animals were better with TCH. The differences in hemoglobin and hematocrit levels, total protein, gamma-globulin and sulfhydryl group quantities, bactericidal and lysozyme activities as well as daily weight gain at the end of treatment/prophylaxis were statistically significant (P<0.

Stimulation of microbial autolytic system by tryptic casein hydrolysate.

Antimicrobial activity of a tryptic casein hydrolysate (TCH), its mode of antimicrobial action and its efficacy in treatment using a newborn calf colibacillosis model are described. The antimicrobial activity of TCH activated the autolytic system of the microbial cell and was expressed mathematically as the autolysis activation index. TCH stimulated the autolytic enzyme system of the 19 bacterial and five fungal strains tested.