Publications by authors named "Teresa Nittoli"
Idiopathic Nephrotic Syndrome (INS) is a common childhood glomerular disease requiring intense immunosuppressive drug treatments. Prediction of treatment response and the occurrence of relapses remains challenging. Biofluid-derived extracellular vesicles (EVs) may serve as novel liquid biopsies for INS classification and monitoring.
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- The study investigates the reasons behind the increased reactivity of T cells in newborns, focusing on specific molecular mechanisms that are not well understood.
- It identifies that neonatal naïve T cells produce more energy and proteins, linked to the lack of LINE1 expression due to specific signaling pathways.
- LINE1 expression increases with age, affecting T cell function and contributing to immune decline as people get older, suggesting its importance throughout human development.
The circadian gene Timeless (TIM) provides a molecular bridge between circadian and cell cycle/DNA replication regulatory systems and has been recently involved in human cancer development and progression. However, its functional role in colorectal cancer (CRC), the third leading cause of cancer-related deaths worldwide, has not been fully clarified yet. Here, the analysis of two independent CRC patient cohorts (total 1159 samples) reveals that loss of TIM expression is an unfavorable prognostic factor significantly correlated with advanced tumor stage, metastatic spreading, and microsatellite stability status.
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