Publications by authors named "Teresa Mitchell-Garcia"
Article Synopsis
- Microglia are the brain's key immune cells, interacting with neurons and other glial cells, crucial for maintaining brain function, and their disruption can lead to neurodegenerative diseases like Alzheimer's and Parkinson's.
- Access to actual human brain tissue is limited, making it challenging to study microglia's role in disease; however, advancements in pluripotent stem cell technology have allowed researchers to create complex models for this purpose.
- Recent developments in brain organoids, which simulate the brain's 3D environment and cellular interactions, are providing new insights into microglial functioning and their potential to investigate various brain pathologies.
Mitochondrial dysfunction mediates neuronal cell response to DMMB photodynamic therapy.
Raphael de Ávila Narciso Gomes Alejandro Marmolejo-Garza Floris-Jan Haan Teresa Mitchell García Tingting Chen
Biochim Biophys Acta Mol Cell Res
March 2023
Photodynamic therapy (PDT) is a process in which a photosensitizer (PS) is exposed to specific wavelengths and generates reactive oxygen species (ROS) which act within nanometers. The low invasive nature and directed cytotoxicity of this approach render it attractive to the treatment of different conditions, including the ones that affect the central nervous system (CNS). The effect of PDT on healthy neurons is one main concern over its use in the CNS, since neuronal-like cells were shown to be particularly sensitive to certain PSs.
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