Morphological changes in adrenal cortex--the final effect of angiotensin II receptor antagonists.

The influence of losartan, angiotensin receptor on the histological image of the adrenal glomerular layer of white rats was revealed. The drug was administered in the therapeutic and ten times higher dose. It was manifested by the decrease of glandular cells and prevalence of blastic cells of the cortex.

Ultrastructure of the hepatocytes after application of azithromycin (Sumamed).

Azithromycin (Sumamed, PLIVA Cracow) was administered intragastrically to rats in doses 10 times and 100 times bigger than the therapeutic dose (according to the indications for a 5-day treatment). Ultrastructural examinations of the liver were performed. Changes observed in the morphology of hepatocytes and Browicz-Kupffer cells (swelling of mitochondria, more numerous lysosomes, weaker RER content and granular material inside biliary canaliculi) may indicate temporary violation of the functional equilibrium in the liver due to the application of azithromycin.

High doses of atorvastatin (Sortis) modify the secretory process in the exocrine portion of the pancreas.

Changes were observed in the ultrastructure of the pancreatic acinar cells in rats after administration of atorvastatin (Sortis) in the therapeutic and ten times larger dose for the period of 6 weeks. It was found that atorvastatin given to rats in the therapeutic dose (80 mg/day) stimulated the secretion in pancreocytes, whereas the ten times higher dose of atorvastatin distorts the complicated process of the release of the secretion from the cell.