Discovering interactions in augmentation strategies: Impact of duloxetine on the metabolism of aripiprazole.

Objective: We aimed to unravel potential pharmacokinetic interactions between aripiprazole and duloxetine.

Methods: Plasma concentrations of aripiprazole in two groups of 78 patients each, receiving aripiprazole as a monotherapy or combined with duloxetine, were compared. A potential impact of duloxetine on the metabolism of aripiprazole was expected in higher plasma concentrations of aripiprazole and higher dose-adjusted plasma concentrations.