Publications by authors named "Teresa Kilian"
Article Synopsis
- - Elevated levels of neutrophils in both blood and tumor tissue of advanced melanoma patients are linked to worse treatment responses and increased therapy resistance.
- - Analysis of patient serum samples and isolated neutrophils showed that neutrophils from melanoma patients had distinct functional characteristics and lower CD16 expression compared to healthy individuals.
- - Neutrophils were found to protect melanoma cells from apoptosis during targeted therapy, suggesting that their protease activity may play a significant role in promoting tumor survival against treatment.
Background: Tebentafusp has recently been approved for the treatment of metastatic uveal melanoma (mUM) after proving to have survival benefits in a first-line setting.
Patients And Methods: This retrospective, multicenter study analyzed the outcomes and safety of tebentafusp therapy in 78 patients with mUM.
Results: Patients treated with tebentafusp had a median PFS of 3 months (95% CI 2.
Background: Eosinophils appear to contribute to the efficacy of immunotherapy and their frequency was suggested as a predictive biomarker. Whether this observation could be transferred to patients treated with targeted therapy remains unknown.
Methods: Blood and serum samples of healthy controls and 216 patients with advanced melanoma were prospectively and retrospectively collected.
Extramedullary disease (EMD) represents a high-risk state of multiple myeloma (MM) associated with poor prognosis. While most anti-myeloma therapeutics demonstrate limited efficacy in this setting, some studies exploring the utility of chimeric antigen receptor (CAR)-modified T cells reported promising results. We have recently designed SLAMF7-directed CAR T cells for the treatment of MM.
View Article and Find Full Text PDFAim: We aimed to analyze the suitability of nanoparticles (M4E) for safe human mesenchymal stem cell (hMSC) labeling and determined cell labeling maintenance in 2D and 3D culture.
Materials & Methods: We investigated cell-particle interaction and the particles' impact on cell viability, growth and proliferation. We analyzed cell labeling maintenance in 2D and 3D culture invasively and noninvasively.