Publications by authors named "Teresa Griffin"
Comparison of the 2007 EORTC/ISCL and the 2022 EORTC/ISCL/USCLC blood staging guidelines for cutaneous T-cell lymphoma at a single institution reveals the newer guidelines fail to detect a subset of patients with Sézary syndrome with low blood burden.
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- Lymphomatoid papulosis (LyP) can present in various ways and may be misdiagnosed as aggressive skin lymphomas, especially those involving γδ T-cells.
- A study analyzed 26 cases of LyP with γδ T-cell expression, noting that most patients were treated with topical steroids or had no treatment.
- The findings highlighted significant differences in how LyP presents, underlining the importance of recognizing specific clinical features and markers to avoid misdiagnosis.
Article Synopsis
- Interstitial mycosis fungoides (IMF) is a rare form of skin lymphoma marked by atypical lymphocyte infiltration in the dermis, presenting with limited skin surface involvement and variable granulomatous characteristics.
- In a study of 31 IMF cases, most patients were male with an average diagnosis age of 43, and symptoms often persisted for about 7 years before diagnosis, with significant clinical remission observed in 52% of patients.
- Pathological analysis showed a predominance of CD4+ lymphocytes in the skin, with notable features including thickened collagen bundles and occasional multinucleated giant cells, indicating IMF's unique indolent nature and its potential to cause alopecia.
Recent studies have shown a close relationship between cutaneous T-cell lymphoma (CTCL) and its microbiome. CTCL disease progression is associated with gut dysbiosis and alterations in bacterial taxa parallel those observed in immunologically similar atopic dermatitis. Moreover, the microbial profile of lesional skin may predict response to narrowband ultraviolet B (nbUVB), a common skin-directed therapy.
View Article and Find Full Text PDFEpstein-Barr virus (EBV)-positive lymphoproliferative disorders associated with immunodeficiency constitute a spectrum of lymphoid and plasma cell proliferations that vary in cytomorphology, immunophenotype, and clinical behavior. CD30-positive cutaneous lymphocytic infiltrates with EBV expression and lymphomatoid papulosis-like presentations have been rarely reported. This retrospective study assessed the clinical and histopathological characteristics of EBV-positive cases with papulonodular morphologies and CD30 positivity seen by Northwestern Medicine Dermatopathology.
View Article and Find Full Text PDFAmerican beavers (Castor canadensis), trapped between 2017 and 2020 for the purpose of translocation, underwent hematologic, serologic, and fecal examinations. Eight of 73 beavers were seropositive for Leptospira spp. and 1/49 seropositive for Toxoplasma gondii.
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