Publications by authors named "Teresa Casuscelli di Tocco"

Iron deficiency and anemia characterize patients on chronic hemodialysis (HD). Available intravenous iron agents, such as ferric gluconate (FG) and ferric carboxymaltose (FCM), vary in dosing regimens and safety profiles. The aim of the present study was to analyze the modification of the iron status, the correction of anemia, and the economic implications after the shift from FG to FCM therapy in chronic HD patients.

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Hemodialysis (HD) is a life-saving therapy for patients with end-stage renal disease. In dialyzed patients, the prevalence of multi-morbidity is rising driven by various factors, such as the population aging, the incomplete correction of uremia, and the side effects of the dialysis therapy itself. Each dialyzed patient has their own specific clinical and biochemical problems.

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Acute and chronic kidney injuries represent critical issues after liver transplantation (LTx), but whereas renal dysfunction in adult transplant patients is well documented, little is known about its prevalence in childhood. It is a challenge to accurately evaluate renal function in patients with liver disease, due to several confounding factors. Creatinine-based equations estimating glomerular filtration rate, validated in nephropathic patients without hepatic issues, are frequently inaccurate in end-stage liver disease, underestimating the real impact of renal disease.

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Article Synopsis
  • Ferric carboxymaltose (FCM) is a new iron treatment for hemodialysis patients that provides advantages over traditional options like ferric gluconate (FX), particularly for managing anemia.
  • Over a 4-year study involving 25 patients, FCM treatment significantly improved iron levels (transferrin saturation) and reduced the need for erythropoietin (EPO) doses compared to FX.
  • The results indicate that FCM effectively maintains stable hemoglobin levels with better anemia control, as evidenced by higher ferritin levels and lower transferrin during treatment.
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