UCP2 Overexpression Redirects Glucose into Anabolic Metabolic Pathways.

Uncoupling protein 2 (UCP2) is often upregulated in cancer cells. The UCP2 upregulation is positively correlated with enhanced proliferation, tumorigenesis, and metabolic alterations, thus suggesting that UCP2 upregulation can play a key role in sensing metabolic changes to promote tumorigenesis. To determine the global metabolic impact of UCP2 upregulation, C glucose as a source molecule is used to "trace" the metabolic fate of carbon atoms derived from glucose.