Publications by authors named "Teresa Blood"
Article Synopsis
- The study aimed to evaluate the effects of intravenous CYT107, a recombinant human IL-7, in sepsis patients, focusing on its ability to reverse lymphopenia and improve immune function.
- Twenty-one patients were enrolled, but the trial was halted early due to adverse reactions in some who received IV CYT107, despite observing increased lymphocyte counts similar to intramuscular administration.
- Ultimately, while IV CYT107 showed effectiveness, it caused transient respiratory distress and is deemed less preferable than intramuscular administration due to better tolerability and pharmacokinetics.
Background: Immunotherapy treatment for coronavirus disease 2019 combined with antiviral therapy and supportive care remains under intense investigation. However, the capacity to distinguish patients who would benefit from immunosuppressive or immune stimulatory therapies remains insufficient. Here, we present a patient with severe coronavirus disease 2019 with a defective immune response, treated successfully with interleukin-7 on compassionate basis with resultant improved adaptive immune function.
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- The paper outlines the impact of COVID-19 on multiple organ systems, highlighting that the virus triggers various inflammatory responses leading to diverse health issues.
- It summarizes research conducted on the mechanisms of how the virus operates within the body, based on expert investigations in critical care medicine.
- The review emphasizes the need for future research to focus on understanding the virus’s effects on organ function to enhance treatment for critically ill patients.
A defining feature of protracted sepsis is development of immunosuppression that is thought to be a major driving force in the morbidity and mortality associated with the syndrome. The immunosuppression that occurs in sepsis is characterized by profound apoptosis-induced depletion of CD4 and CD8 T cells and severely impaired T cell function. OX40, a member of the TNF receptor superfamily, is a positive co-stimulatory molecule expressed on activated T cells.
View Article and Find Full Text PDFCOVID-19-associated morbidity and mortality have been attributed to a pathologic host response. Two divergent hypotheses have been proposed: hyperinflammatory cytokine storm; and failure of host protective immunity that results in unrestrained viral dissemination and organ injury. A key explanation for the inability to address this controversy has been the lack of diagnostic tools to evaluate immune function in COVID-19 infections.
View Article and Find Full Text PDFBackground: A defining pathophysiologic feature of sepsis is profound apoptosis-induced death and depletion of CD4+ and CD8+ T cells. Interleukin-7 (IL-7) is an antiapoptotic common γ-chain cytokine that is essential for lymphocyte proliferation and survival. Clinical trials of IL-7 in over 390 oncologic and lymphopenic patients showed that IL-7 was safe, invariably increased CD4+ and CD8+ lymphocyte counts, and improved immunity.
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