Publications by authors named "Teresa A York"
Rhabdomyosarcoma is the most common soft tissue sarcoma in children and adolescents. Embryonal rhabdomyosarcoma (ERMS), its most common subtype, is a malignant soft tissue tumor with morphologic and immunophenotypic features of embryonic skeletal muscle. The histologic findings in ERMS typically include a range of differentiation in rhabdomyoblasts from primitive to terminally differentiated forms, and the latter become more prominent after chemotherapy-induced cytodifferentiation.
View Article and Find Full Text PDFMelanotic Neuroectodermal Tumor of Infancy: Case Report and Review of Management.
J Oral Maxillofac Surg
February 2019
Melanotic neuroectodermal tumor of infancy (MNTI) is a rare pigmented tumor of the head and neck, which most commonly presents during the first year of life. Most cases present in the bones of the craniofacial region, including the maxilla (60.3%), skull (18.
View Article and Find Full Text PDFArticle Synopsis
- A CCRF-CEM mutant, referred to as CEM-p, shows resistance to methotrexate due to lower accumulation of its polyglutamate forms.
- Researchers investigated the underlying mechanisms by analyzing the expression of FPGS and SLC19A1 mRNA, assessing FPGS promoter activity, and sequencing the FPGS promoter and cDNA from both CCRF-CEM and CEM-p cells.
- The study identified three amino acid changes in FPGS from CEM-p cells that impact ATP binding, glutamate/folate binding, and a critical conserved domain, highlighting the essential role of this domain for FPGS functionality.