GenerateHope: a comprehensive treatment model for sex-trafficked women.

GenerateHope (GH) is a San Diego-based 501c3 nonprofit organization providing fully integrated, comprehensive rehabilitation services to adult female survivors of sex trafficking. While best practices for working with survivors of sex trafficking are slowly emerging, to date, there have been few publications on this subject and little data on either short- or long-term outcomes from the many and varied programs nationwide. This paper examines the GH residential program and provides early outcome results for residents living at the GH program between six and 12 months.

Unexpected renal toxicity associated with SGX523, a small molecule inhibitor of MET.

Purpose: SGX523 is an orally bio-available, ATP competitive, small molecule inhibitor of MET, binding the kinase domain active site in a novel mode. Two phase 1, open-label, dose-escalation studies of SGX523 were conducted to evaluate both interrupted and continuous dosing schedules.

Methods: Thirty-six patients per study were planned to be enrolled.