Publications by authors named "Terence Li"
Article Synopsis
- The study examines the roles of the hippocampus and prefrontal cortex in learning and cognition, focusing on their molecular development through innovative genomic techniques.
- Researchers used over 53,000 single-nucleus profiles to analyze DNA methylation and chromatin conformation changes, finding that these processes occur at different times during development.
- The findings reveal distinct chromatin interactions in neurons versus glial cells and identify specific genetic variants associated with schizophrenia, highlighting the potential of single-cell multi-omics in understanding brain development and neuropsychiatric disorders.
Article Synopsis
- CDK9 is a key regulator of mRNA transcription and is increasingly recognized as a target for cancer therapy due to its role in promoting cancer cell growth and poor patient outcomes.
- Recent research is expanding the focus on CDK9's implications not just in blood cancers, but also in solid tumors, where it is often overexpressed and drives oncogenic processes.
- This review highlights recent findings about CDK9 in solid tumors, evaluates small molecule inhibitors targeting CDK9, and discusses the latest clinical trial results while addressing considerations for enhancing the effectiveness of these therapies.
Colorectal cancer (CRC) is a heterogeneous disease with a myriad of alterations at the cellular and molecular levels. Kristen rat sarcoma (KRAS) mutations occur in up to 40% of CRCs and serve as both a prognostic and predictive biomarker. Oncogenic mutations in the KRAS protein affect cellular proliferation and survival, leading to tumorigenesis through RAS/MAPK pathways.
View Article and Find Full Text PDFNew psychoactive substances (NPS) emerge continually, amongst which is a growing class of ketamine analogues with an arylcyclohexylamine backbone. Recently we reported a poisoning outbreak associated with 2-oxo-PCE (deschloro-N-ethyl-ketamine). The present report describes the emergence of another ketamine analogue, 2-fluorodeschloroketamine (2F-DCK).
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