Bridging the gap between non-canonical and canonical Wnt signaling through Vangl2.

Non-canonical Wnt signaling (encompassing Wnt/PCP and WntCa) has a dual identity in the literature. One stream of research investigates its role in antagonizing canonical Wnt/β-catenin signaling in cancer, typically through Ca, while the other stream investigates its effect on polarity in development, typically through Vangl2. Rarely do these topics intersect or overlap.