Stroke Onset Time Determination Using MRI Relaxation Times without Non-Ischaemic Reference in A Rat Stroke Model.

Background: Objective timing of stroke in emergency departments is expected to improve patient stratification. Magnetic resonance imaging (MRI) relaxations times, T and T , in abnormal diffusion delineated ischaemic tissue were used as proxies of stroke time in a rat model.

Methods: Both 'non-ischaemic reference'-dependent and -independent estimators were generated.