The Formation of Non-Specific Immunological Memory Phenotype in Human Monocyte-Like THP-1 and U-937 Cell Lines.

We studied the formation of the phenotype of non-specific immunological memory (trained immunity) in human monocyte-like THP-1 and U-937 cell lines. The absence of the lag phase after primary contact with the pathogen (Mycobacterium bovis, BCG vaccine) does not contribute to the formation of the trained immunity phenotype in the cells. The presence of the lag phase promotes the development of the trained immunity phenotype, especially in THP-1 cells.

Clinical characteristics and risk factors for disease severity and mortality of COVID-19 patients with diabetes mellitus in Kazakhstan: A nationwide study.

Background: Diabetes mellitus (DM) is associated with higher risk of developing infectious disease and COVID-19 is not the exception. There is a need to generate more data on clinical characteristics and risks of COVID19 patients presenting with DM. In this retrospective study we aimed to report on demographic features, clinical data, and outcomes of COVID-19 patients with DM in comparison with age- and sex-matched patients without DM.

[Assessment of caries risk factors among school-age children by comparing EGOHID scores in Minsk and Moscow].

The aim of the study was to assess the acceptability of the objective and subjective indicators for identification of oral diseases risk factors and the quality of dental care of school-aged children. The study included 200 school children of two age groups (12 and 15-year-old) surveyed in Minsk and Moscow cities using European global system of oral health indicators development (EGOHID). The modified WHO questionnaire was used to study behavioral habits of 15-year-old children.

[Dependence of caries protective effect of fluoride varnishes applications on first permanent molars in schoolchildren on the intensity of caries of temporary teeth].

There are four-year clinical research results of the efficacy of the varnishes with different fluoride compounds on first permanent molars in young schoolchildren depending on the lesion of caries of temporary molars. It was determined that for children, whose molars were healthy during the basic examination, the highest caries protective effect was achieved with the help of varnish, containing CaF(2) (the reduction of increase of the intensity of caries of permanent molars formed 59.7%), and for children with initial high lesion of caries of permanent molars the best caries preventive effect was achieved with the varnish "Bifluorid 12®" (the reduction of increase of the intensity of caries of permanent molars formed 52.

[Fluoride in children saliva with its natural low intake in cases of fluoridated salt or water consumption].

Fluoride content dynamics in whole saliva in 3 groups of 5-6 year old children before and after meal. All children lived in the region with lov F-0,2 ppm in water, used fluoridated toothpaste and went to kindergartens. Children from group A (n=10) did not have other sources of F, group B children (n=10) drink one glass a day of F-water (1 ppm), participants from group C (n=11) eat F-salt 250+/-100 ppm.

[The influence of sodium nitroprusside, the possible donor of nitric oxide on activity ATPases and lipid peroxidation of erythrocytes of sick children].

The effect of sodium nitroprusside, possible nitric oxide donor, on the activities of Ca2+, Mg(2+)- and Na+, K(+)-ATPases and lipid peroxidation was investigated in erythrocytes in vitro. Sodium nitroprusside caused 3-fold increase of mechanical and peroxidative erythrocyte hemolysis and also increase of bound malonic dialdehyde. Sodium nitroprusside-treated erythrocytes were also characterized by increased Na+, K(+)-ATPase activity.

[A trial of performing dental caries prevention in preschoolers with fluoridated salt].

Fluorinated salt was added to rations of preschool children for preventing dental caries. The program was implemented in 1411 children for 1 year, in 1438 for 2 years, in 1070 for 3 years, and in 1056 children for 4 years. The study was carried out in children attending kindergartens in Minsk, Mogilev, Mozyr, Nesvizh, and Baranovichi.

[Ways to improve the caries resistance of the temporary teeth by using fluoridated salt].

The content of calcium and phosphorus is decreased and that of fluorine increased in the oral fluid of children whose diet includes fluorinated salt, and the levels of calcium and phosphorus in their dental enamel are increased in comparison with children using common table salt. Three-year consumption of fluorinated salt resulted in a decrease of calcium release and increase of phosphorus release into acid biopsy.

[The nonspecific resistance of the oral cavity in preschool children during the prevention of dental caries with fluoridated salt].

Nonspecific resistance of the oral cavity was studied from microorganism adsorption in children using fluorinated table salt for the prevention of dental caries. Epitheliocytes with a high adsorption capacity were detected in smears from preschool children using fluorinated salt for 2 and 3 years 1.5 and 1.

[Effects of school environment factors on enterobiasis morbidity among students].

The authors examined 20 general educational schools in Rostov-on-Don and identified 8 informative determinants of enterobiasis prevalence among them, such as the frequency of wet cleaning, the number of recreational rooms and gymnasia, over-crowding, the presence of extended-day groups, water supply, shower-rooms in the gymnasia, and shifts of educational processes.

[Significance of personal hygiene habits in the prevention of enterobiasis].

The pupils from Rostov-on-Don were interviewed by a questionnaire on medical helminthology. They were found to poor knowledge in this sphere. They do not observe elementary personal hygienic rules.

[Study of risk factors of enterobiasis in schoolchildren and development of a prognostic table for primary screening].

Risk factors for enterobiasis were qualitatively and quantitatively assessed by a questionnaire given to 277 health schoolchildren and 277 schoolchildren who suffered from enterobiasis. A prognostic table was developed for primary screening of risk groups. Preventive measures are recommended in the paper.

[The use of emakor in arterial ischemia of the lower extremities in outpatient practice].

Overall 43 outpatients with arterial ischemia of the lower limbs were treated by emakor, a new Soviet drug that exerts a concomitant alpha- and beta-blocking action. The treatment resulted in a remarkable positive effect which manifested itself in amelioration of circulation in the lower limbs, positive time-course of changes in peripheral hemodynamics and in computer-aided tomography data. The use of emakor is contraindicated in exacerbation of gastrointestinal diseases, chronic pulmonary diseases associated with the obstructive syndrome, and marked signs of venous outflow obstruction in the lower limbs.

[Use of the early autopsy method for the morphofunctional substantiation of liver failure].

The authors made a biochemical comparative analysis of the blood taken during early autopsies from the portal and hepatic veins and structural-metabolic state of the liver tissue. It is concluded that this analysis is of great importance for morphofunctional substantiation of hepatic insufficiency.

[Effect of low-energy laser radiation on the levels of cyclic nucleotides and lactic acid of the mucous membranes in gastric and duodenal ulcers].

The level of cyclic nucleotides in biological material undergoes changes due to endoscopic treatment of gastric and duodenal ulcers with the help of helium-neon laser radiation which, in addition to dynamics of the clinical picture and gastroduodenoscopic data, makes it possible to diagnose the disease remission and in certain cases to predict the course of peptic ulcer.

[Temporary disability in patients with acute pneumonia at an outpatient clinic].

Temporary disability was analysed for 186 patients with acute pneumonia (AP) treated in outpatient clinics. On demand, the patients were referred to hospitals. The disability duration was assessed in relation to the patients' age, associated diseases, smoking, time to diagnosis and hospitalization.

[Biochemical and morphofunctional changes in the myocardium of dogs with occlusion of the terminal portion of the aorta].

The occlusion of the terminal aortic region was experimentally induced in 48 dogs. It has been shown that myocardial lesions localized predominantly in the papillary muscles and subendocardially appear already 3 hours after the occlusion. The number of the affected cardiomyocytes increases and their size enlarges.

[Prostaglandin and cyclic nucleotide content of the ventricular myocardium in noradrenaline damage to the heart].

The effect of intraperitoneal noradrenaline injection (2.5 mg/kg body weight) on myocardial levels of cAMP, cHMP, PGE and PGF2 alpha of the left and right ventricles was examined in male Wistar rats. The findings were compared with morphologic changes in the myocardium and sympathetic nerves of both ventricles.