Publications by authors named "Terada J"
Background: No previous studies have compared respiratory clinics and respiratory specialized facilities regarding causative diseases for bloody sputum and hemoptysis in Japan.
Methods: We retrospectively compared causative diseases for bloody sputum and hemoptysis between 3 respiratory clinics (clinic group) and 7 departments of respiratory medicine at hospitals (hospital group) in Japan.
Results: We collected data from 231 patients (median age, 51 years; age range, 24-96 years; 109 men (47.
Background: Biologics are integral in the management of severe asthma. As the effectiveness of the anti-IL-5 receptor antibody benralizumab in Japan remains elusive, this study aimed to assess its real-world effectiveness in Japanese patients with severe asthma.
Methods: This prospective, interventional, single-arm clinical trial was conducted across ten facilities in Japan between September 2020 and July 2022.
Article Synopsis
- Obesity-hypoventilation syndrome (OHS) is a severe respiratory condition linked to morbid obesity, often treated with positive airway pressure therapies and weight loss.
- A case study of a 53-year-old woman with a BMI of 49 kg/m² showed she suffered from acute respiratory failure due to OHS, requiring mechanical ventilation and significant weight loss of over 30 kg.
- Despite her weight loss, continuous monitoring indicated that factors beyond obesity affected her respiratory health, suggesting that simply losing weight may not be enough to stop NPPV treatment for OHS.
Article Synopsis
- Werner's syndrome is a rare disorder that causes symptoms resembling advanced aging and is associated with serious complications, particularly malignancies.
- A 54-year-old woman with Werner's syndrome was found to have a rare case of lung cancer after an abnormal shadow was seen in her chest x-ray, leading to further examinations.
- She was diagnosed with stage IA3 squamous cell carcinoma, successfully underwent surgery for removal, and remained cancer-free for two years following the operation.
Article Synopsis
- The Japanese Respiratory Society's 2019 guidelines on managing cough and sputum were the first internationally recognized, but the data was not sourced from Japan.
- A retrospective study analyzed 556 patients in Japan with bloody sputum or hemoptysis, identifying bronchiectasis, lung cancer, and non-tuberculous mycobacterial disease as the main causes.
- The study highlighted that the causes varied significantly by sex and age, indicating that personalized approaches based on these factors are crucial for understanding and treating these conditions.
Background: This study aimed to develop and validate claims-based algorithms for identifying hospitalized patients with coronavirus disease 2019 (COVID-19) and disease severity.
Methods: We used claims data including all patients at the National Center for Global and Medicine Hospital between January 1, 2020, and December 31, 2021. The claims-based algorithms for three statuses with COVID-19 (hospitalizations, moderate or higher status, and severe status) were developed using diagnosis codes (International Classification of Diseases, 10 revision code: U07.
Article Synopsis
- The study evaluated the LC16m8 vaccine's safety and effectiveness against the monkeypox virus (MPXV) in 50 healthy adults over 168 days.
- On day 28, the vaccine showed strong immunogenicity, with 72% to 88% seroconversion rates, although these rates declined by day 168.
- Adverse events were common but mostly mild, and no serious safety issues or cases of monkeypox were reported during the study period.
Background: Autoantibodies develop in autoimmune diseases, cancer, diabetes mellitus (DM), and atherosclerosis-related diseases. However, autoantibody biomarkers have not been successfully examined for diagnosis and therapy.
Methods: Serological identification of antigens through recombinant cDNA expression cloning (SEREX) was used for primary screening of antigens.
Article Synopsis
- A study was conducted to evaluate the effectiveness of convalescent plasma therapy for COVID-19 in high-risk patients who showed symptoms within five days.
- The trial involved 25 patients, with no significant difference in viral load changes between those receiving convalescent plasma and those receiving standard care over the first five days.
- The results suggest that early convalescent plasma treatment does not reduce SARS-CoV-2 viral load compared to standard care alone within that timeframe.
Background: Dexamethasone, remdesivir, and baricitinib reduce mortality in patients with coronavirus disease 2019 (COVID-19). A single-arm study using combination therapy with all three drugs reported low mortality in patients with severe COVID-19. In this clinical setting, whether dexamethasone administered as a fixed dose of 6 mg has sufficient inflammatory modulation effects of reducing lung injury has been debated.
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- Pulmonary tumor thrombotic microangiopathy is a severe condition where tumor cells block small blood vessels in the lungs, leading to symptoms like difficulty breathing and heart failure, often seen in advanced cancer cases.
- A 68-year-old woman with non-small cell lung cancer, who was responding well to treatment, suddenly experienced worsening breathlessness and fatigue, despite no signs of tumor progression on imaging.
- An autopsy revealed that while her primary tumor had shrunk, tumor clusters still caused significant blockage in lung vessels, highlighting that this condition can occur even with effective cancer treatment.
High-flow nasal cannula (HFNC) can be effective in treating type 1 respiratory failure by reducing the severity of coronavirus disease 2019 (COVID-19). The purpose of this study was to assess the reduction of disease severity and safety of HFNC treatment in patients with severe COVID-19. We retrospectively observed 513 consecutive patients with COVID-19 admitted to our hospital from January 2020 to January 2021.
View Article and Find Full Text PDFBackground: The 6-min walk test (6MWT) is a common assessment of exercise-induced hypoxemia and exercise capacity used in patients with chronic fibrosing interstitial pneumonia (CFIP). However, whether the dynamic changes in S and heart rate during the 6MWT are associated with mortality in patients with CFIP has been undefined.
Methods: This retrospective study enrolled 63 subjects with mild to severe CFIP who underwent the 6MWT.
Background: We aimed to assess differences in health literacy between those who improved CPAP non-adherent and those who remained non-adherent.
Methods: We included patients newly diagnosed with sleep apnea syndrome who had started CPAP therapy between February 2019 and October 2020 with ≥6 follow-up months or who self-interrupted CPAP therapy <6 months. We recorded the CPAP wearing time after 3 and 6 months.
Article Synopsis
- * Initial treatment included four cycles of chemotherapy, which successfully eradicated all detectable cancer lesions.
- * After a recurrence of the tumor, the patient underwent a combination of additional chemotherapy and extensive surgical intervention, leading to a complete remission lasting over 2.5 years, suggesting the potential effectiveness of salvage surgery for this type of cancer.
Multiple Cavitary Lung Metastases from Prostate Adenocarcinoma.
Am J Respir Crit Care Med
April 2023
Background And Objective: The possibility of combination therapy with atomoxetine (ATO) and oxybutynin (OXY) has been suggested for obstructive sleep apnoea (OSA). However, the effectiveness of this treatment remains uninvestigated in Japanese OSA patients. Therefore, we performed a randomized, crossover, phase II, single-centre prospective trial to examine the effects of ATO-OXY therapy in Japanese OSA patients.
View Article and Find Full Text PDFSuvorexant (Belsomra(R)), a dual orexin receptor antagonist widely used in the treatment of insomnia, inhibits the arousal system in the brain. However, the drug's ventilatory effects have not been fully explored. This study aims to investigate the expression of orexin receptors in respiratory neurons and the effects of suvorexant on ventilation.
View Article and Find Full Text PDFObjectives: This study aims to create and validate a useful score system predicting the hyper-inflammatory conditions of COVID-19, by comparing it with the modified H-score.
Methods: A total of 98 patients with pneumonia (without oxygen therapy) who received initial administration of casirivimab/imdevimab or remdesivir were included in the study. The enrolled patients were divided into two groups: patients who required corticosteroid due to deterioration of pneumonia, assessed by chest X-ray or CT or respiratory failure, and those who did not, and clinical parameters were compared.
The long-term effects of using a high-flow nasal cannula for chronic hypercapnic respiratory failure caused by chronic obstructive pulmonary disease remain unclear. To assess whether long-term high-flow nasal cannula use reduces the number of exacerbations and improves other physiological parameters in patients with chronic hypercapnic respiratory failure caused by chronic obstructive pulmonary disease. We enrolled 104 participants (aged ⩾40 yr) with daytime hypercapnia (Global Initiative for Chronic Obstructive Lung Disease stages 2-4) receiving long-term oxygen therapy (⩾16 h/d for ⩾1 mo) and randomly assigned them to high-flow nasal cannula/long-term oxygen therapy and long-term oxygen therapy groups.
View Article and Find Full Text PDFBackground: The effectiveness of combination therapy for COVID-19 pneumonia remains unclear. We evaluated favipiravir, camostat, and ciclesonide combination therapy in patients with moderate COVID-19 pneumonia.
Methods: In this open-label phase 3 study, hospitalized adults who were positive for SARS-CoV-2 and had COVID-19 pneumonia were enrolled prior to official vaccination drive in Japan.
Coronavirus disease 2019 (COVID-19) is a novel emerging disease and a major risk factor for postoperative complications, especially in thoracic surgery. However, it is unclear how previous COVID-19 infection may affect perioperative management of lung resection patients. A 70-year-old woman visited her primary doctor complaining of chest pain.
View Article and Find Full Text PDFBackground/aim: Nab-paclitaxel (Nab-PTX) has been widely used to treat several advanced cancers. Nab-PTX can cause drug-induced lung injury (DILI); however, its clinical and radiographic features have not been clarified. We aimed to assess the clinical characteristics of Nab-PTX-induced lung injury and identify its associated risk factors.
View Article and Find Full Text PDFWe report the case of a 29-year-old man who underwent umbilical cord blood transplantation for chronic myelogenous leukemia 14 years previously. He was diagnosed with secondary pleuroparenchymal fibroelastosis (sPPFE) following treatment for hematologic malignancies (sPPFE after HM-Tx) 2.5 years ago.
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