Synthesis and biological evaluation of 1,2-disubsubstituted 4-quinolone analogues of sp. natural products.

A series of analogues of sp. natural products were synthesized, which have been reported to possess potent antibacterial activity against and induce growth defects in and . Taking inspiration from a methodology used in our total synthesis of natural products, we applied this methodology to access analogues possessing bulky N-substituents, traditionally considered to be challenging scaffolds.