Dental Pulp Vascular Response to Early Stages of Caries.

Objectives: During caries progression, dental pulp is increasingly pathologically affected. Since the accurate assessment of pulp is of vital importance in clinical decision-making, this study aimed to evaluate pulpal condition in the early stages of caries via laser Doppler (LD) flowmetry and histologic analysis and determine their agreement.

Methods: Fourteen patients with severe dental crowding were included.

Assessment of dental pulp response to carries via MR Tmapping and histological analysis.

Objectives: The aim of our study was to assess the correlation between T relaxation times and their variability with the histopathological results of the same teeth in relation to caries progression.

Materials And Methods: 52 extracted permanent premolars were included in the study. Prior to extractions, patients underwent magnetic resonance imaging (MRI) scanning and teeth were evaluated using ICDAS classification.

Expression of CD31, CD34, and smooth muscle actin (SMA) in endothelial cells of dental pulp vessels.

The dental pulp is a highly vascularized and innervated loose connective tissue surrounded by hard dental tissues - enamel and dentine. With the primary dentin formation and the closure of the root apex, the conditions in the dental pulp change and pulp tissue compliance are reduced. Endothelial cells of pulpal blood vessels are highly differentiated and are capable of adaptation to changes in the environment.

Optimization of Large Vessel Occlusion Detection in Acute Ischemic Stroke Using Machine Learning Methods.

The early detection of large-vessel occlusion (LVO) strokes is increasingly important as these patients are potential candidates for endovascular therapy, the availability of which is limited. Prehospital LVO detection scales mainly contain symptom variables only; however, recent studies revealed that other types of variables could be useful as well. Our aim was to comprehensively assess the predictive ability of several clinical variables for LVO prediction and to develop an optimal combination of them using machine learning tools.

Comparison of the vitality tests used in the dental clinical practice and histological analysis of the dental pulp.

In dentistry, indirect diagnostic methods such as electrical sensibility testing and pulse oximetry are used to assess the status of the pulp. Our study aimed to determine the correlation between hemoglobin oxygen saturation and vascular volume density (Vvasc). We also wanted to examine an electrical sensibility test and the volume density of myelinated nerve fibers (Vnerv).

Measurement of Pressures Generated in Root Canal During Er:YAG Laser-Activated Irrigation.

To measure distribution of pressures along the depth of the root canal during erbium-doped yttrium aluminum garnet (Er:YAG) laser-activated irrigation (LAI) with different modalities and fiber tip (FT) geometries. A new LAI modality based on the delivery of synchronized pairs of Er:YAG laser pulses to generate enhanced irrigant streaming and shock wave emission was recently introduced. However, the influence of FT geometry on efficacy and comparison with single pulse modality is not yet presented.

Evaluation of Apical Extrusion During Novel Er:YAG Laser-Activated Irrigation Modality.

To evaluate apical extrusion during a novel erbium-doped yttrium aluminum garnet (Er:YAG) laser-activated irrigation (LAI) modality. : A novel double-pulse Er:YAG modality (AutoSWEEPS) was introduced recently, replacing a single laser pulse with two micropulses that are separated by a varying time delay (which is continuously "swept" between 300 and 600 μsec). Although the proposed method demonstrated increased efficacy, no data were yet available on extrusion.

Paradigm changes for diagnosis: using big data for prediction.

Due to profound changes occurring in biomedical knowledge and in health systems worldwide, an entirely new health and social care scenario is emerging. Moreover, the enormous technological potential developed over the last years is increasingly influencing life sciences and driving changes toward personalized medicine and value-based healthcare. However, the current slow progression of adoption, limiting the generation of healthcare efficiencies through technological innovation, can be realistically overcome by fostering convergence between a systems medicine approach and the principles governing Integrated Care.

Population-based analysis of patients with COPD in Catalonia: a cohort study with implications for clinical management.

Background: Clinical management of patients with chronic obstructive pulmonary disease (COPD) shows potential for improvement provided that patients' heterogeneities are better understood. The study addresses the impact of comorbidities and its role in health risk assessment.

Objective: To explore the potential of health registry information to enhance clinical risk assessment and stratification.

Network modules uncover mechanisms of skeletal muscle dysfunction in COPD patients.

Background: Chronic obstructive pulmonary disease (COPD) patients often show skeletal muscle dysfunction that has a prominent negative impact on prognosis. The study aims to further explore underlying mechanisms of skeletal muscle dysfunction as a characteristic systemic effect of COPD, potentially modifiable with preventive interventions (i.e.

ChainRank, a chain prioritisation method for contextualisation of biological networks.

Background: Advances in high throughput technologies and growth of biomedical knowledge have contributed to an exponential increase in associative data. These data can be represented in the form of complex networks of biological associations, which are suitable for systems analyses. However, these networks usually lack both, context specificity in time and space as well as the distinctive borders, which are usually assigned in the classical pathway view of molecular events (e.

The COPD Knowledge Base: enabling data analysis and computational simulation in translational COPD research.

Background: Previously we generated a chronic obstructive pulmonary disease (COPD) specific knowledge base (http://www.copdknowledgebase.eu) from clinical and experimental data, text-mining results and public databases.

Systems Medicine: from molecular features and models to the clinic in COPD.

Background And Hypothesis: Chronic Obstructive Pulmonary Disease (COPD) patients are characterized by heterogeneous clinical manifestations and patterns of disease progression. Two major factors that can be used to identify COPD subtypes are muscle dysfunction/wasting and co-morbidity patterns. We hypothesized that COPD heterogeneity is in part the result of complex interactions between several genes and pathways.

[Jugular chemodectoma with Garcin syndrome].

The authors present an exceptional case of chemodectoma jugulare with important invasion of the skull base involving all the cranial nerves on one side and conforming Garcin's syndrome. Practically all the possible ways of spreading were followed by the tumor, with involvement of the posterior, middle and anterior fossas of the skull base and also orbit, middle ear and neck. The clinical and histopathological difficulties in the diagnosis, especially when the chemodectoma has only neurological signs, are stressed.

[Surgery by anterior approach in cervical myelopathy with a narrow canal].

Twenty four patients with spastic paraparesis due to cervical myelopathy were operated on by the anterior approach. They all received anterior cervical discectomy and/or osteophytes resection with the operating microscope, without fusion. There were no deaths and no one deteriorated after surgery.

[Embolization with adipose tissue (author's transl)].

The authors present their animal experimental work on adipose tissue as an occlusive agent, using the renal and carotid areas as parenchyma in which to test its effect. Work was planned in four series: the first with a survival rate of 24 to 72 h, the second with a survival rate of 7 to 18 days, the third, 45 to 58 days, and the fourth, 58 to 90 days. Angiographic and anatomopathologic postembolization controls were performed, thus supplying conclusive radiologic and histologic documentation on the embolization material under study.

[Pott's disease of cervical topography. Apropos of a case].

The authors present a case of cervical Pott's disease with severe neurological impairment and with a favourable course with medical and surgical treatment. The diagnostic difficulties and the possibilities of treatment at the present stage are discussed.

[Memory disorders in posterior vertebrobasilar cerebral artery insufficiency].

A clinical and neuropsychological study of 10 vascular patients with signs of circulatory insufficiency in the vertebro-basilar-posterior cerebral territory in whom the dominant symptom was loss of memory with relative idemnity of other intelectual functions is presented. In 5 cases clinical signs of acute infarct in the posterior cerebral artery territories existed in the form of amnesic infarct. The disturbances and the localization of the lesion confirmed by paraclinical examinations (EEG, angiography of the posterior circulation, radioisotope scan) are discussed.